Literature DB >> 25955202

Modeling the aging heart: from local respiratory defects to global rhythm disturbances.

Konstantin Khrapko1, Natalia Trayanova2, Stanley Nattel3.   

Abstract

In this issue, Baris et al. (2015) describe cardiac rhythm abnormalities in a mouse model of mitochondrial dysfunction in widely distributed cells of the aging human heart. How do a few metabolically challenged cells disrupt cardiac rhythm? We suggest that these cells provide "crystallization centers" for latent dysfunctional zones to allow arrhythmia emergence.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 25955202      PMCID： PMC4816650          DOI： 10.1016/j.cmet.2015.04.024

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  10 in total

1.  Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia.

Authors:  J Wanagat; Z Cao; P Pathare; J M Aiken
Journal:  FASEB J       Date:  2001-02       Impact factor: 5.191

Review 2.  Role of the autonomic nervous system in atrial fibrillation: pathophysiology and therapy.

Authors:  Peng-Sheng Chen; Lan S Chen; Michael C Fishbein; Shien-Fong Lin; Stanley Nattel
Journal:  Circ Res       Date:  2014-04-25       Impact factor: 17.367

Review 3.  Mitochondrial DNA mutations in aging.

Authors:  Konstantin Khrapko; Doug Turnbull
Journal:  Prog Mol Biol Transl Sci       Date:  2014       Impact factor: 3.622

Review 4.  Cardiac ionic currents and acute ischemia: from channels to arrhythmias.

Authors:  E Carmeliet
Journal:  Physiol Rev       Date:  1999-07       Impact factor: 37.312

Review 5.  New directions in cardiac arrhythmia management: present challenges and future solutions.

Authors:  Stanley Nattel; Jason Andrade; Laurent Macle; Lena Rivard; Katia Dyrda; Blandine Mondesert; Paul Khairy
Journal:  Can J Cardiol       Date:  2014-09-30       Impact factor: 5.223

6.  Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions.

Authors:  K Khrapko; N Bodyak; W G Thilly; N J van Orsouw; X Zhang; H A Coller; T T Perls; M Upton; J Vijg; J Y Wei
Journal:  Nucleic Acids Res       Date:  1999-06-01       Impact factor: 16.971

7.  Cytochrome-c-oxidase deficient cardiomyocytes in the human heart--an age-related phenomenon. A histochemical ultracytochemical study.

Authors:  J Müller-Höcker
Journal:  Am J Pathol       Date:  1989-05       Impact factor: 4.307

8.  Redox modification of ryanodine receptors by mitochondria-derived reactive oxygen species contributes to aberrant Ca2+ handling in ageing rabbit hearts.

Authors:  Leroy L Cooper; Weiyan Li; Yichun Lu; Jason Centracchio; Radmila Terentyeva; Gideon Koren; Dmitry Terentyev
Journal:  J Physiol       Date:  2013-09-16       Impact factor: 5.182

Review 9.  Epidemiology of arrhythmias and conduction disorders in older adults.

Authors:  Grant V Chow; Joseph E Marine; Jerome L Fleg
Journal:  Clin Geriatr Med       Date:  2012-11       Impact factor: 3.076

10.  Mosaic Deficiency in Mitochondrial Oxidative Metabolism Promotes Cardiac Arrhythmia during Aging.

Authors:  Olivier R Baris; Stefan Ederer; Johannes F G Neuhaus; Jürgen-Christoph von Kleist-Retzow; Claudia M Wunderlich; Martin Pal; F Thomas Wunderlich; Viktoriya Peeva; Gabor Zsurka; Wolfram S Kunz; Tilman Hickethier; Alexander C Bunck; Florian Stöckigt; Jan W Schrickel; Rudolf J Wiesner
Journal:  Cell Metab       Date:  2015-05-05       Impact factor: 27.287
  10 in total
  1 in total

1.  A Simple, Non-Invasive Score to Predict Paroxysmal Atrial Fibrillation.

Authors:  Stefan M Kallenberger; Christian Schmid; Felix Wiedmann; Derliz Mereles; Hugo A Katus; Dierk Thomas; Constanze Schmidt
Journal:  PLoS One       Date:  2016-09-28       Impact factor: 3.240
  1 in total

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