Literature DB >> 25954598

Healing after death: antitumor immunity induced by oncolytic adenoviral therapy.

Hong Jiang1, Juan Fueyo1.   

Abstract

We recently evaluated the capacity of Delta-24-RGD oncolytic adenovirus to trigger an antitumor immune response in a syngeneic mouse glioma model. This virotherapy elicited immunity against both tumor-associated antigens and viral antigens. An immunogenic cell death accompanied by pathogen- or damage- associated patterns (PAMPs and DAMPs) induced by the virus may be responsible for the adenoviral-mediated antitumor effect.

Entities:  

Keywords:  antitumor immunity; danger (or damage)-associated molecular patterns (DAMPs); immunogenic cell death; oncolytic adenovirus; pathogen-associated patterns (PAMPs)

Year:  2014        PMID: 25954598      PMCID: PMC4355947          DOI: 10.4161/21624011.2014.947872

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN: 2162-4011            Impact factor:   8.110


  10 in total

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