| Literature DB >> 25954598 |
Hong Jiang1, Juan Fueyo1.
Abstract
We recently evaluated the capacity of Delta-24-RGD oncolytic adenovirus to trigger an antitumor immune response in a syngeneic mouse glioma model. This virotherapy elicited immunity against both tumor-associated antigens and viral antigens. An immunogenic cell death accompanied by pathogen- or damage- associated patterns (PAMPs and DAMPs) induced by the virus may be responsible for the adenoviral-mediated antitumor effect.Entities:
Keywords: antitumor immunity; danger (or damage)-associated molecular patterns (DAMPs); immunogenic cell death; oncolytic adenovirus; pathogen-associated patterns (PAMPs)
Year: 2014 PMID: 25954598 PMCID: PMC4355947 DOI: 10.4161/21624011.2014.947872
Source DB: PubMed Journal: Oncoimmunology ISSN: 2162-4011 Impact factor: 8.110