Literature DB >> 2595371

A model of human acute lymphoblastic leukemia in immune-deficient SCID mice.

S Kamel-Reid1, M Letarte, C Sirard, M Doedens, T Grunberger, G Fulop, M H Freedman, R A Phillips, J E Dick.   

Abstract

A human acute lymphoblastic leukemia (ALL) cell line that was transplanted into immune-deficient SCID mice proliferated in the hematopoietic tissues, invaded various organs, and led to the death of the mice. The distribution of leukemic cells in SCID mice was similar to the course of the disease in children. A-1 cells marked with a retrovirus vector showed clonal evolution after the transplant. SCID mice that were injected with bone marrow from three patients with non-T ALL had leukemic cells in their bone marrow and spleen. This in vivo model of human leukemia is an approach to understanding leukemic growth and progression and is a novel system for testing new treatment strategies.

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Year:  1989        PMID： 2595371     DOI： 10.1126/science.2595371

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  51 in total

Review 1.  Human cancer growth and therapy in immunodeficient mouse models.

Authors:  Leonard D Shultz; Neal Goodwin; Fumihiko Ishikawa; Vishnu Hosur; Bonnie L Lyons; Dale L Greiner
Journal:  Cold Spring Harb Protoc       Date:  2014-07-01

2.  Novel in vivo model of inducible multi-drug resistance in acute lymphoblastic leukemia with chromosomal translocation t(4;11).

Authors:  Susan J Zunino; David H Storms; Jonathan M Ducore
Journal:  Cancer Lett       Date:  2010-04-09       Impact factor: 8.679

3.  Hemagglutination and graft-versus-host disease in the severe combined immunodeficiency mouse lymphoproliferative disease model.

Authors:  S J Pirruccello; H Nakamine; K W Beisel; K L Kleveland; M Okano; Y Taguchi; J R Davis; M L Mahloch; D T Purtilo
Journal:  Am J Pathol       Date:  1992-05       Impact factor: 4.307

4.  Suppression of Philadelphia1 leukemia cell growth in mice by BCR-ABL antisense oligodeoxynucleotide.

Authors:  T Skorski; M Nieborowska-Skorska; N C Nicolaides; C Szczylik; P Iversen; R V Iozzo; G Zon; B Calabretta
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-10       Impact factor: 11.205

Review 5.  Biology of normal and acute myeloid leukemia stem cells.

Authors:  John E Dick; Tsvee Lapidot
Journal:  Int J Hematol       Date:  2005-12       Impact factor: 2.490

6.  Development of functional human NK cells in an immunodeficient mouse model with the ability to provide protection against tumor challenge.

Authors:  Amanda Kwant-Mitchell; Elishka A Pek; Kenneth L Rosenthal; Ali A Ashkar
Journal:  PLoS One       Date:  2009-12-21       Impact factor: 3.240

7.  Validation of a mouse xenograft model system for gene expression analysis of human acute lymphoblastic leukaemia.

Authors:  Amy L Samuels; Violet K Peeva; Rachael A Papa; Marin J Firth; Richard W Francis; Alex H Beesley; Richard B Lock; Ursula R Kees
Journal:  BMC Genomics       Date:  2010-04-21       Impact factor: 3.969

8.  Gain-of-function mutations of the p53 gene induce lymphohematopoietic metastatic potential and tissue invasiveness.

Authors:  M Hsiao; J Low; E Dorn; D Ku; P Pattengale; J Yeargin; M Haas
Journal:  Am J Pathol       Date:  1994-09       Impact factor: 4.307

Review 9.  Potential of the scid mouse as a host for human tumors.

Authors:  B M Mueller; R A Reisfeld
Journal:  Cancer Metastasis Rev       Date:  1991-10       Impact factor: 9.264

10.  An in vivo model of human multidrug-resistant multiple myeloma in SCID mice.

Authors:  W T Bellamy; A Odeleye; P Finley; B Huizenga; W S Dalton; R S Weinstein; E M Hersh; T M Grogan
Journal:  Am J Pathol       Date:  1993-03       Impact factor: 4.307
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