E Stevens1, S Andreasen2, K Bjørndal3, P Homøe4. 1. Department of Otorhinolaryngology and Maxillofacial Surgery, Køge University Hospital, Lykkebækvej 1, 4600 Køge, Denmark; University of Copenhagen, Faculty of Health and Medical Sciences, Blegdamsvej 3b, 2200 Copenhagen N, Denmark. Electronic address: Elizabeth.stevens@live.dk. 2. Department of Otorhinolaryngology and Maxillofacial Surgery, Køge University Hospital, Lykkebækvej 1, 4600 Køge, Denmark; University of Copenhagen, Faculty of Health and Medical Sciences, Blegdamsvej 3b, 2200 Copenhagen N, Denmark; Department of Otorhinolaryngology Head and Neck Surgery and Audiology, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark. Electronic address: smnndrsn@gmail.com. 3. Department of ENT Head and Neck Surgery, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark. Electronic address: kristine.bjoerndal@rsyd.dk. 4. Department of Otorhinolaryngology and Maxillofacial Surgery, Køge University Hospital, Lykkebækvej 1, 4600 Køge, Denmark; University of Copenhagen, Faculty of Health and Medical Sciences, Blegdamsvej 3b, 2200 Copenhagen N, Denmark. Electronic address: prho@regionsjaelland.dk.
Abstract
INTRODUCTION: Tumors of the parotid gland in children are rare and very little data has been published regarding the incidence of these tumors. We present a nationwide survey on this topic. METHODS: Data regarding benign and malignant tumors in the parotid gland in children from January 1st, 1990 to December 31st, 2005 in Denmark was collected retrospectively from nationwide registries. This generated 61 patients for inclusion in this study. RESULTS: 85% of the tumors were benign and the malignant tumors made up the last 15%. The most common of the malignant tumors was the acinic cell carcinoma (n=4) followed by the mucoepidermoid carcinoma (n=3) and adenoid cystic carcinoma (n=2). The overall female-to-male ratio was 1.18, with a ratio of 1.08 and 2.0 in the benign and malignant groups, respectively. At the end of follow-up (August 1st, 2014) two patients had died, one with adenoid cystic carcinoma and one with mucoepidermoid carcinoma. Both patients had perineural invasion and involved resection margins at presentation. The incidence was 0.12 and 0.53 per 100,000 children of the malignant and benign tumors, respectively. CONCLUSION: Pleomorphic adenomas were the predominant neoplasm in the parotid gland in children. The most frequent of the malignant tumors was the acinic cell carcinoma, which is in contrast to previous studies. The proportion of malignant-to-benign parotid gland tumors is in contrast to earlier study reports not higher in children than in adults.
INTRODUCTION:Tumors of the parotid gland in children are rare and very little data has been published regarding the incidence of these tumors. We present a nationwide survey on this topic. METHODS: Data regarding benign and malignant tumors in the parotid gland in children from January 1st, 1990 to December 31st, 2005 in Denmark was collected retrospectively from nationwide registries. This generated 61 patients for inclusion in this study. RESULTS: 85% of the tumors were benign and the malignant tumors made up the last 15%. The most common of the malignant tumors was the acinic cell carcinoma (n=4) followed by the mucoepidermoid carcinoma (n=3) and adenoid cystic carcinoma (n=2). The overall female-to-male ratio was 1.18, with a ratio of 1.08 and 2.0 in the benign and malignant groups, respectively. At the end of follow-up (August 1st, 2014) two patients had died, one with adenoid cystic carcinoma and one with mucoepidermoid carcinoma. Both patients had perineural invasion and involved resection margins at presentation. The incidence was 0.12 and 0.53 per 100,000 children of the malignant and benign tumors, respectively. CONCLUSION: Pleomorphic adenomas were the predominant neoplasm in the parotid gland in children. The most frequent of the malignant tumors was the acinic cell carcinoma, which is in contrast to previous studies. The proportion of malignant-to-benign parotid gland tumors is in contrast to earlier study reports not higher in children than in adults.
Authors: Hani Ibrahim Channir; Thomas van Overeem Hansen; Simon Andreasen; Christina Westmose Yde; Katalin Kiss; Birgitte Wittenborg Charabi Journal: Head Neck Pathol Date: 2017-02-16
Authors: Simone de Campos Vieira Abib; Chan Hon Chui; Sharon Cox; Abdelhafeez H Abdelhafeez; Israel Fernandez-Pineda; Ahmed Elgendy; Jonathan Karpelowsky; Pablo Lobos; Marc Wijnen; Jörg Fuchs; Andrea Hayes; Justin T Gerstle Journal: Ecancermedicalscience Date: 2022-02-17