Literature DB >> 25953155

Design and synthesis of close analogs of LCRF-0004, a potent and selective RON receptor tyrosine kinase inhibitor.

Stéphane L Raeppel1, Franck Raeppel2, Eric Therrien2.   

Abstract

New carboxamide head group analogs of thieno[3,2-b]pyridine-based kinase inhibitor LCRF-0004 were designed and synthesized. Potent and selective inhibitors of RON enzyme versus c-Met RTK were obtained.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Head group; Oncology; RON; RTK inhibitors; Thieno[3,2-b]pyridine scaffold; c-Met

Mesh：

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Year:  2015        PMID： 25953155     DOI： 10.1016/j.bmcl.2015.04.056

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

Review 1.  Strategies of targeting the extracellular domain of RON tyrosine kinase receptor for cancer therapy and drug delivery.

Authors:  Omid Zarei; Silvia Benvenuti; Fulya Ustun-Alkan; Maryam Hamzeh-Mivehroud; Siavoush Dastmalchi
Journal:  J Cancer Res Clin Oncol       Date:  2016-08-08       Impact factor: 4.553

2.  Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer.

Authors:  Liang Feng; Hang-Ping Yao; Yong-Qing Zhou; Jianwei Zhou; Ruiwen Zhang; Ming-Hai Wang
Journal:  J Exp Clin Cancer Res       Date:  2016-04-22

3.  When RON MET TAM in Mesothelioma: All Druggable for One, and One Drug for All?

Authors:  Anne-Marie Baird; David Easty; Monika Jarzabek; Liam Shiels; Alex Soltermann; Sonja Klebe; Stéphane Raeppel; Lauren MacDonagh; Chengguang Wu; Kim Griggs; Michaela B Kirschner; Bryan Stanfill; Daisuke Nonaka; Chandra M Goparaju; Bruno Murer; Dean A Fennell; Dearbhaile M O'Donnell; Martin P Barr; Luciano Mutti; Glen Reid; Stephen Finn; Sinead Cuffe; Harvey I Pass; Isabelle Opitz; Annette T Byrne; Kenneth J O'Byrne; Steven G Gray
Journal:  Front Endocrinol (Lausanne)       Date:  2019-02-26       Impact factor: 5.555
  3 in total

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