Kirsten van Kessel1, Trecia Wouldes2, Rona Moss-Morris3. 1. Department of Psychology AUT University, Auckland, New Zealand kvankess@aut.ac.nz. 2. Department of Psychological Medicine, University of Auckland, Auckland, New Zealand. 3. Section of Health Psychology, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
Abstract
OBJECTIVE: To pilot and compare the efficacy of an internet-based cognitive behavioural therapy self-management programme with (MSInvigor8-Plus) and without (MSInvigor8-Only) the use of email support in reducing fatigue severity and impact (primary outcomes), and depressed and anxious mood (secondary outcomes). DESIGN: Randomized controlled trial using an independent randomization system built into the website and intention-to-treat analysis. SETTING:Participants were recruited through the local Multiple Sclerosis Society and hospital neurological services in New Zealand. SUBJECTS: A total of 39 people (aged 31-63 years), experiencing multiple sclerosis fatigue, able to walk with and without walking aids, were randomized to MSInvigor8-Only (n = 20) or to MSInvigor8-Plus (n = 19). INTERVENTIONS: MSInvigor8 is an eight-session programme based on cognitive behaviour therapy principles including psycho-education, self-monitoring, and changing unhelpful activity and thought patterns. MAIN MEASURES: Outcome measures included fatigue severity (Chalder Fatigue Scale) and impact (Modified Fatigue Impact Scale), and anxiety and depression (Hospital Anxiety and Depression Scale). Assessments were performed at baseline and at 10 weeks. RESULTS: The MSInvigor8-Plus condition resulted in significantly greater reductions in fatigue severity (F [1,36] = 9.09, p < 0.01) and impact (F [1,36] = 6.03, p < 0.02) compared with the MSInvigor8-Only condition. Large between-group effect sizes for fatigue severity (d = 0.99) and fatigue impact (d = 0.81) were obtained. No significant differences were found between the groups on changes in anxiety and depression. CONCLUSIONS: MSInvigor8 delivered with email-based support is a potentially promising, acceptable, and cost-effective approach to treating fatigue in people with multiple sclerosis in New Zealand.
RCT Entities:
OBJECTIVE: To pilot and compare the efficacy of an internet-based cognitive behavioural therapy self-management programme with (MSInvigor8-Plus) and without (MSInvigor8-Only) the use of email support in reducing fatigue severity and impact (primary outcomes), and depressed and anxious mood (secondary outcomes). DESIGN: Randomized controlled trial using an independent randomization system built into the website and intention-to-treat analysis. SETTING:Participants were recruited through the local Multiple Sclerosis Society and hospital neurological services in New Zealand. SUBJECTS: A total of 39 people (aged 31-63 years), experiencing multiple sclerosis fatigue, able to walk with and without walking aids, were randomized to MSInvigor8-Only (n = 20) or to MSInvigor8-Plus (n = 19). INTERVENTIONS: MSInvigor8 is an eight-session programme based on cognitive behaviour therapy principles including psycho-education, self-monitoring, and changing unhelpful activity and thought patterns. MAIN MEASURES: Outcome measures included fatigue severity (Chalder Fatigue Scale) and impact (Modified Fatigue Impact Scale), and anxiety and depression (Hospital Anxiety and Depression Scale). Assessments were performed at baseline and at 10 weeks. RESULTS: The MSInvigor8-Plus condition resulted in significantly greater reductions in fatigue severity (F [1,36] = 9.09, p < 0.01) and impact (F [1,36] = 6.03, p < 0.02) compared with the MSInvigor8-Only condition. Large between-group effect sizes for fatigue severity (d = 0.99) and fatigue impact (d = 0.81) were obtained. No significant differences were found between the groups on changes in anxiety and depression. CONCLUSIONS: MSInvigor8 delivered with email-based support is a potentially promising, acceptable, and cost-effective approach to treating fatigue in people with multiple sclerosis in New Zealand.
Authors: Aliza Ben-Zacharia; Meagan Adamson; Allison Boyd; Paula Hardeman; Jennifer Smrtka; Bryan Walker; Tracy Walker Journal: Int J MS Care Date: 2018 Nov-Dec
Authors: Kirsten Van Kessel; Duncan R Babbage; Nicholas Reay; Warren M Miner-Williams; Paula Kersten Journal: JMIR Mhealth Uhealth Date: 2017-02-28 Impact factor: 4.773
Authors: Aung Zaw Zaw Phyo; Thibaut Demaneuf; Alysha M De Livera; George A Jelinek; Chelsea R Brown; Claudia H Marck; Sandra L Neate; Keryn L Taylor; Taylor Mills; Emily O'Kearney; Amalia Karahalios; Tracey J Weiland Journal: Front Neurol Date: 2018-04-04 Impact factor: 4.003
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