Literature DB >> 25952516

Hyperpolarized Gas MR Imaging: Technique and Applications.

Justus E Roos1, Holman P McAdams2, S Sivaram Kaushik3, Bastiaan Driehuys4.   

Abstract

Functional imaging offers information more sensitive to changes in lung structure and function. Hyperpolarized helium ((3)He) and xenon ((129)Xe) MR imaging of the lungs provides sensitive contrast mechanisms to probe changes in pulmonary ventilation, microstructure, and gas exchange. Gas imaging has shifted to the use of (129)Xe. Xenon is well-tolerated. (129)Xe is soluble in pulmonary tissue, which allows exploring specific lung function characteristics involved in gas exchange and alveolar oxygenation. Hyperpolarized gases and (129)Xe in particular stand to be an excellent probe of pulmonary structure and function, and provide sensitive and noninvasive biomarkers for pulmonary diseases.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Hyperpolarized gas; Lung imaging; MR imaging; Pulmonary gas exchange; Pulmonary ventilation; Xenon ((129)Xe)

Mesh：

Substances：

Year:  2015        PMID： 25952516      PMCID： PMC4428591          DOI： 10.1016/j.mric.2015.01.003

Source DB:  PubMed          Journal:  Magn Reson Imaging Clin N Am        ISSN： 1064-9689            Impact factor:   2.266


  43 in total

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4.  Measuring diffusion limitation with a perfusion-limited gas--hyperpolarized 129Xe gas-transfer spectroscopy in patients with idiopathic pulmonary fibrosis.

Authors:  S Sivaram Kaushik; Matthew S Freeman; Suk W Yoon; Maria G Liljeroth; Jane V Stiles; Justus E Roos; W Michael Foster; Craig R Rackley; H P McAdams; Bastiaan Driehuys
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8.  Solubility of inert gases in biological fluids and tissues: a review.

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9.  Regional mapping of gas uptake by blood and tissue in the human lung using hyperpolarized xenon-129 MRI.

Authors:  Kun Qing; Kai Ruppert; Yun Jiang; Jaime F Mata; G Wilson Miller; Y Michael Shim; Chengbo Wang; Iulian C Ruset; F William Hersman; Talissa A Altes; John P Mugler
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  28 in total

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Review 3.  Probing carbohydrate metabolism using hyperpolarized 13 C-labeled molecules.

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Review 5.  The role of hyperpolarized 129xenon in MR imaging of pulmonary function.

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6.  Mapping cardiopulmonary dynamics within the microvasculature of the lungs using dissolved 129Xe MRI.

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7.  Multireader Determination of Clinically Significant Obstruction Using Hyperpolarized 129Xe-Ventilation MRI.

Authors:  Lukas Ebner; Rohan S Virgincar; Mu He; Kingshuk R Choudhury; Scott H Robertson; Andreas Christe; Achille Mileto; Joseph G Mammarapallil; H Page McAdams; Bastiaan Driehuys; Justus E Roos
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8.  Preclinical hyperpolarized 129 Xe MRI: ventilation and T2 * mapping in mouse lungs at 7 T using multi-echo flyback UTE.

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