Moonyoung Chung1, Young Seok Park2, Ji Seon Kim3, Yun Joong Kim4, Hyeo Il Ma4, Su Jin Jang5, Ryoong Huh1, Hyun Sook Kim6, Won-Chan Kim6. 1. Department of Neurosurgery, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, South Korea. 2. Department of Neurosurgery, Chungbuk National University Hospital, Chungbuk National University, College of Medicine, 410 SungBong-Ro, Heungdeok-gu, Cheongju-Si, 361-763, Korea. youngseokparkmd@gmail.com. 3. Department of Neurosurgery, Chungbuk National University Hospital, Chungbuk National University, College of Medicine, 410 SungBong-Ro, Heungdeok-gu, Cheongju-Si, 361-763, Korea. 4. Department of Neurology, Hallym Medical Center, Hallym University College of Medicine, Chuncheon, South Korea. 5. Department of Nuclear Medicine, CHA University School of Medicine, Seongnam, Korea. 6. Department of Neurology Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.
Abstract
PURPOSE: To investigate the correlation between the striatal three-dimensional location and the Unified Parkinson's Disease Rating Scale (UPDRS) motor score in the context of idiopathic Parkinson's disease (PD) through radiolabeled N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane positron emission tomography/computed tomography (FP-CIT PET/CT). MATERIALS AND METHODS: In this cross-sectional study, we assessed the UPDRS motor score and performed FP-CIT PET/CT in patients with PD. Thirty-eight patients with idiopathic PD [average 70 years of age (range 49-86); male:female ratio 12:26] were enrolled. The correlation between FP-CIT PET/CT and the UPDRS III scores was investigated after the transformation of PET images by an alternative method using MATLAB. RESULTS: Left caudate nucleus uptake negatively correlated with UPDRS items 18, 20 (face), 22 (right arm and leg), 23, 24 (right side), 26 (right side), 27, 30, and 31, while right caudate nucleus uptake positively correlated with items 18, 22 (left arm), 26, and 29. Putamen uptake correlated with items 22 and 25. Left caudate nucleus uptake positively correlated with axial and akinetic-rigidity symptoms. CONCLUSIONS: FP-CIT uptake in specific basal ganglia structures strongly correlated with the UPDRS III motor score. Among these, the left caudate nucleus exhibited the strongest relationship with axial and akinetic-rigidity PD symptoms.
PURPOSE: To investigate the correlation between the striatal three-dimensional location and the Unified Parkinson's Disease Rating Scale (UPDRS) motor score in the context of idiopathic Parkinson's disease (PD) through radiolabeled N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane positron emission tomography/computed tomography (FP-CIT PET/CT). MATERIALS AND METHODS: In this cross-sectional study, we assessed the UPDRS motor score and performed FP-CIT PET/CT in patients with PD. Thirty-eight patients with idiopathic PD [average 70 years of age (range 49-86); male:female ratio 12:26] were enrolled. The correlation between FP-CIT PET/CT and the UPDRS III scores was investigated after the transformation of PET images by an alternative method using MATLAB. RESULTS: Left caudate nucleus uptake negatively correlated with UPDRS items 18, 20 (face), 22 (right arm and leg), 23, 24 (right side), 26 (right side), 27, 30, and 31, while right caudate nucleus uptake positively correlated with items 18, 22 (left arm), 26, and 29. Putamen uptake correlated with items 22 and 25. Left caudate nucleus uptake positively correlated with axial and akinetic-rigidity symptoms. CONCLUSIONS:FP-CIT uptake in specific basal ganglia structures strongly correlated with the UPDRS III motor score. Among these, the left caudate nucleus exhibited the strongest relationship with axial and akinetic-rigidity PD symptoms.
Authors: Li Jun Zuo; Shu Yang Yu; Fang Wang; Yang Hu; Ying Shan Piao; Yang Du; Teng Hong Lian; Rui Dan Wang; Qiu Jin Yu; Ya Jie Wang; Xiao Min Wang; Piu Chan; Sheng Di Chen; Yongjun Wang; Wei Zhang Journal: J Clin Neurol Date: 2016-02-04 Impact factor: 3.077
Authors: George Edward Calver Thomas; Louise Ann Leyland; Anette-Eleonore Schrag; Andrew John Lees; Julio Acosta-Cabronero; Rimona Sharon Weil Journal: J Neurol Neurosurg Psychiatry Date: 2020-02-20 Impact factor: 10.154