OBJECTIVES: An overview of molecular tests used in the treatment of breast cancer, organized by stage and clinical condition. DATA SOURCES: Systematic review of scientific literature, guideline recommendations, and data published by test manufacturers. CONCLUSION: Several molecular tests that analyze expression of cancer-related genes have been validated in clinical trials and are recommended by clinical practice guidelines to inform diagnosis and treatment decisions for personalized interventions. IMPLICATIONS FOR NURSING PRACTICE: Molecular testing has become an important part of patient care for those with breast cancer. Oncology nurses must understand this methodology to prescribe tests, interpret the results, and provide guidance to patients. Published by Elsevier Inc.
OBJECTIVES: An overview of molecular tests used in the treatment of breast cancer, organized by stage and clinical condition. DATA SOURCES: Systematic review of scientific literature, guideline recommendations, and data published by test manufacturers. CONCLUSION: Several molecular tests that analyze expression of cancer-related genes have been validated in clinical trials and are recommended by clinical practice guidelines to inform diagnosis and treatment decisions for personalized interventions. IMPLICATIONS FOR NURSING PRACTICE: Molecular testing has become an important part of patient care for those with breast cancer. Oncology nurses must understand this methodology to prescribe tests, interpret the results, and provide guidance to patients. Published by Elsevier Inc.
Entities:
Keywords:
Breast gene expression; breast cancer subtypes; molecular diagnostics; molecular test
Authors: Dara L Aisner; Mathew D Rumery; Daniel T Merrick; Kimi L Kondo; Hala Nijmeh; Derek J Linderman; Robert C Doebele; Natalie Thomas; Patrick C Chesnut; Marileila Varella-Garcia; Wilbur A Franklin; D Ross Camidge Journal: Arch Pathol Lab Med Date: 2016-09-09 Impact factor: 5.534
Authors: Lea V Weber; Klaudia Al-Refae; Gerhard Wölk; Gabriele Bonatz; Janine Altmüller; Christian Becker; Günter Gisselmann; Hanns Hatt Journal: Breast Cancer (Dove Med Press) Date: 2016-12-13