OBJECTIVES: To describe the currently available genetic tests that identify hereditary risk for breast cancer. DATA SOURCES: Systematic review of scientific literature, clinical practice guidelines, and data published by test manufacturers. CONCLUSION: Changes in gene patent laws and advances in sequencing technologies have resulted in rapid expansion of genetic testing. While BRCA1/2 are the most recognized genes linked to breast cancer, several laboratories now offer multi-gene panels to detect many risk-related mutations. IMPLICATIONS FOR NURSING PRACTICE: Genetic testing will be increasingly important in the prevention, diagnosis, and treatment of breast cancer. Oncology and advanced practice nurses must understand risk factors, significance of various genetic tests, and patient counseling. Published by Elsevier Inc.
OBJECTIVES: To describe the currently available genetic tests that identify hereditary risk for breast cancer. DATA SOURCES: Systematic review of scientific literature, clinical practice guidelines, and data published by test manufacturers. CONCLUSION: Changes in gene patent laws and advances in sequencing technologies have resulted in rapid expansion of genetic testing. While BRCA1/2 are the most recognized genes linked to breast cancer, several laboratories now offer multi-gene panels to detect many risk-related mutations. IMPLICATIONS FOR NURSING PRACTICE: Genetic testing will be increasingly important in the prevention, diagnosis, and treatment of breast cancer. Oncology and advanced practice nurses must understand risk factors, significance of various genetic tests, and patient counseling. Published by Elsevier Inc.
Authors: Susan M Domchek; Tara M Friebel; Christian F Singer; D Gareth Evans; Henry T Lynch; Claudine Isaacs; Judy E Garber; Susan L Neuhausen; Ellen Matloff; Rosalind Eeles; Gabriella Pichert; Laura Van t'veer; Nadine Tung; Jeffrey N Weitzel; Fergus J Couch; Wendy S Rubinstein; Patricia A Ganz; Mary B Daly; Olufunmilayo I Olopade; Gail Tomlinson; Joellen Schildkraut; Joanne L Blum; Timothy R Rebbeck Journal: JAMA Date: 2010-09-01 Impact factor: 56.272
Authors: Francisco J Dominguez; Julie L Jones; Katherina Zabicki; Barbara L Smith; Michele A Gadd; Michele Specht; Daniel B Kopans; Richard H Moore; James S Michaelson; Kevin S Hughes Journal: Cancer Date: 2005-11-01 Impact factor: 6.860
Authors: Ann Marie Augustyn; Nicole M Agostino; Tara L Namey; Suresh Nair; Martin A Martino Journal: Breast Cancer Res Treat Date: 2011-05-24 Impact factor: 4.872
Authors: M Robson; M K Dabney; G Rosenthal; S Ludwig; M H Seltzer; T Gilewski; B Haas; M Osborne; L Norton; F Gilbert; K Offit Journal: Genet Test Date: 1997
Authors: Kelly A Metcalfe; Aletta Poll; Robert Royer; Marcia Llacuachaqui; Anna Tulman; Ping Sun; Steven A Narod Journal: J Clin Oncol Date: 2009-12-14 Impact factor: 44.544
Authors: Christina D Williams; Alyssa Jasmine Bullard; Meghan O'Leary; Reana Thomas; Thomas S Redding; Karen Goldstein Journal: J Racial Ethn Health Disparities Date: 2019-04-08
Authors: M A Rosales-Reynoso; V Rosas-Enríquez; A M Saucedo-Sariñana; M Pérez-Coria; M P Gallegos-Arreola; E Salas-González; P Barros-Núñez; C I Juárez-Vázquez; S E Flores-Martínez; J Sánchez-Corona Journal: Br J Biomed Sci Date: 2022-01-25 Impact factor: 2.432
Authors: Maria C Katapodi; Valeria Viassolo; Maria Caiata-Zufferey; Christos Nikolaidis; Nicole Buerki; Karl Heinimann; Viola Heinzelmann-Schwarz; Olivia Pagani; Pierre O Chappuis; Rosmarie Bührer-Landolt; Rossella Graffeo; Henrik Csaba Horváth; Christian Kurzeder; Manuela Rabaglio; Michael Scharfe; Corinne Urech; Tobias E Erlanger; Nicole Probst-Hensch Journal: JMIR Res Protoc Date: 2017-09-20
Authors: Konrad Buscher; Erik Ehinger; Pritha Gupta; Akula Bala Pramod; Dennis Wolf; George Tweet; Calvin Pan; Charles D Mills; Aldons J Lusis; Klaus Ley Journal: Nat Commun Date: 2017-07-24 Impact factor: 14.919
Authors: Maria C Katapodi; Miyeon Jung; Ann M Schafenacker; Kara J Milliron; Kari E Mendelsohn-Victor; Sofia D Merajver; Laurel L Northouse Journal: JMIR Cancer Date: 2018-04-13
Authors: Prisca O Adejumo; Toyin I G Aniagwu; Olutosin A Awolude; Abiodun O Oni; Olubunmi O Ajayi; Omolara Fagbenle; Dasola Ogungbade; Makayla Kochheiser; Temidayo Ogundiran; Olufunmilayo I Olopade Journal: Ecancermedicalscience Date: 2021-09-07