Chang-Ching Wei1, Cheng-Li Lin2, Te-Chun Shen3, Chia-Hung Kao4. 1. 1] Children's Hospital, China Medical University Hospital, Taichung, Taiwan [2] College of Medicine, China Medical University, Taichung, Taiwan. 2. 1] College of Medicine, China Medical University, Taichung, Taiwan [2] Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan. 3. 1] College of Medicine, China Medical University, Taichung, Taiwan [2] Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Taichung, Taiwan. 4. 1] Graduate Institute of Clinical Medicine Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan [2] Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan.
Abstract
BACKGROUND: Only a few studies have systemically analyzed the association between neonatal jaundice and childhood-onset allergic diseases. METHODS: From 2000 to 2007, 27,693 neonates with newly diagnosed neonatal jaundice and 55,367 matched nonneonatal jaundice cohorts were identified. The incidences and hazard ratios (HRs) of five allergic diseases, namely allergic conjunctivitis (AC), allergic rhinitis (AR), atopic dermatitis (AD), asthma, and urticaria, by the end of 2008 were calculated. RESULTS: The incidence density and HRs of the five allergic diseases were greater in the neonatal jaundice cohort than in the nonneonatal jaundice cohort, and the HRs declined modestly with age. The HRs for AR (HR = 2.51, 95% confidence interval (CI) = 2.43-2.59) and AD (HR = 2.51, 95% CI = 2.40-2.62) were the highest, and that for urticaria was the lowest (HR = 2.06, 95% CI = 1.94-2.19). The HRs of allergic diseases were substantially greater for boys and those requiring phototherapy. The HRs of the allergic diseases, except urticaria (HR = 2.49, 95% CI = 1.57-3.97), were not significantly different between the neonatal jaundice regardless of whether the patients received exchange transfusion. CONCLUSION: Neonatal jaundice is associated with the development of allergic diseases in early childhood.
BACKGROUND: Only a few studies have systemically analyzed the association between neonatal jaundice and childhood-onset allergic diseases. METHODS: From 2000 to 2007, 27,693 neonates with newly diagnosed neonatal jaundice and 55,367 matched nonneonatal jaundice cohorts were identified. The incidences and hazard ratios (HRs) of five allergic diseases, namely allergic conjunctivitis (AC), allergic rhinitis (AR), atopic dermatitis (AD), asthma, and urticaria, by the end of 2008 were calculated. RESULTS: The incidence density and HRs of the five allergic diseases were greater in the neonatal jaundice cohort than in the nonneonatal jaundice cohort, and the HRs declined modestly with age. The HRs for AR (HR = 2.51, 95% confidence interval (CI) = 2.43-2.59) and AD (HR = 2.51, 95% CI = 2.40-2.62) were the highest, and that for urticaria was the lowest (HR = 2.06, 95% CI = 1.94-2.19). The HRs of allergic diseases were substantially greater for boys and those requiring phototherapy. The HRs of the allergic diseases, except urticaria (HR = 2.49, 95% CI = 1.57-3.97), were not significantly different between the neonatal jaundice regardless of whether the patients received exchange transfusion. CONCLUSION:Neonatal jaundice is associated with the development of allergic diseases in early childhood.
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