OBJECTIVE: To assess if the allelic variations of rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene cluster are associated with smoking cessation after nicotine replacement therapy (NRT). METHODS: We searched for NRT studies published from 2000-2013 that reported counts for allelic variation of rs16969968/rs1051730 and measured abstinence rates at the end of NRT treatment. We identified four studies which met the criteria, giving us a test sample of 2036 participants. RESULTS: There was no effect of rs16969968/rs1051730 in influencing the success rate at the end of NRT (n = 6, effect size [ES]: 0.969, 95% CI: 0.77 to 1.23, z = 0.27, p = 0.791). CONCLUSION: There is no robust evidence that allelic variations of rs16969968 or rs1051730 are associated with smoking cessation after NRT. Original submitted 26 November 2014; Revision submitted 9 March 2015.
OBJECTIVE: To assess if the allelic variations of rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene cluster are associated with smoking cessation after nicotine replacement therapy (NRT). METHODS: We searched for NRT studies published from 2000-2013 that reported counts for allelic variation of rs16969968/rs1051730 and measured abstinence rates at the end of NRT treatment. We identified four studies which met the criteria, giving us a test sample of 2036 participants. RESULTS: There was no effect of rs16969968/rs1051730 in influencing the success rate at the end of NRT (n = 6, effect size [ES]: 0.969, 95% CI: 0.77 to 1.23, z = 0.27, p = 0.791). CONCLUSION: There is no robust evidence that allelic variations of rs16969968 or rs1051730 are associated with smoking cessation after NRT. Original submitted 26 November 2014; Revision submitted 9 March 2015.
Authors: Alex T Ramsey; Li-Shiun Chen; Sarah M Hartz; Nancy L Saccone; Sherri L Fisher; Enola K Proctor; Laura J Bierut Journal: Transl Behav Med Date: 2018-01-29 Impact factor: 3.046
Authors: Hamdi Mbarek; Catharina E M van Beijsterveldt; Jouke Jan Hottenga; Conor V Dolan; Dorret I Boomsma; Gonneke Willemsen; Jacqueline M Vink Journal: Nicotine Tob Res Date: 2019-05-21 Impact factor: 4.244
Authors: Bader Chaarani; Kees-Jan Kan; Scott Mackey; Philip A Spechler; Alexandra Potter; Catherine Orr; Nicholas D'Alberto; Kelsey E Hudson; Tobias Banaschewski; Arun L W Bokde; Uli Bromberg; Christian Büchel; Anna Cattrell; Patricia J Conrod; Sylvane Desrivières; Herta Flor; Vincent Frouin; Jürgen Gallinat; Penny Gowland; Andreas Heinz; Bernd Ittermann; Jean-Luc Martinot; Frauke Nees; Dimitri Papadopoulos-Orfanos; Tomáš Paus; Luise Poustka; Michael N Smolka; Henrik Walter; Robert Whelan; Stephen T Higgins; Gunter Schumann; Robert R Althoff; Elliot A Stein; Hugh Garavan Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2019-03-15
Authors: Henry R Kranzler; Rachel V Smith; Robert Schnoll; Afaf Moustafa; Emma Greenstreet-Akman Journal: Addiction Date: 2017-04-21 Impact factor: 6.526
Authors: Ewoud Schuit; Orestis A Panagiotou; Marcus R Munafò; Derrick A Bennett; Andrew W Bergen; Sean P David Journal: Cochrane Database Syst Rev Date: 2017-09-08
Authors: Nancy L Saccone; James W Baurley; Andrew W Bergen; Sean P David; Hannah R Elliott; Marilyn G Foreman; Jaakko Kaprio; Thomas M Piasecki; Caroline L Relton; Laurie Zawertailo; Laura J Bierut; Rachel F Tyndale; Li-Shiun Chen Journal: Nicotine Tob Res Date: 2018-03-06 Impact factor: 4.244