Literature DB >> 25949888

Targeting leukemia by CD1c-restricted T cells specific for a novel lipid antigen.

Marco Lepore1, Claudia de Lalla2, Lucia Mori3, Paolo Dellabona2, Gennaro De Libero3, Giulia Casorati2.   

Abstract

A subset of CD1c-restricted T lymphocytes exhibits strong reactivity against leukemia cells. These T cells recognize methyl-lysophosphatidic acid (mLPA), a novel lipid antigen produced by acute leukemia cells. Considering that CD1c-restricted T cells display efficacious anti-leukemia activities in a mouse model, this lipid antigen thus represents a novel target in the immunotherapy of hematological malignancies.

Entities:  

Keywords:  CD1; autoreactivity; immunesurveillance; immunotherapy; leukemia; lipid antigens

Year:  2014        PMID： 25949888      PMCID： PMC4404883          DOI： 10.4161/21624011.2014.970463

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

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Authors:  E Gilboa
Journal:  Immunity       Date:  1999-09       Impact factor: 31.745

Review 2.  The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids.

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Review 3.  Recognition of lipid antigens by T cells.

Authors:  Gennaro De Libero; Lucia Mori
Journal:  Nat Rev Immunol       Date:  2005-06       Impact factor: 53.106

Review 4.  Peroxisomes and oxidative stress.

Authors:  Michael Schrader; H Dariush Fahimi
Journal:  Biochim Biophys Acta       Date:  2006-09-14

Review 5.  Adoptive immunotherapy for cancer or viruses.

Authors:  Marcela V Maus; Joseph A Fraietta; Bruce L Levine; Michael Kalos; Yangbing Zhao; Carl H June
Journal:  Annu Rev Immunol       Date:  2014-01-09       Impact factor: 28.527

Review 6.  Peroxisomes, lipid metabolism and lipotoxicity.

Authors:  R J A Wanders; S Ferdinandusse; P Brites; S Kemp
Journal:  Biochim Biophys Acta       Date:  2010-01-12

7.  Lysophosphatidylmethanol is a pan lysophosphatidic acid receptor agonist and is produced by autotaxin in blood.

Authors:  Tomoko Endo; Kuniyuki Kano; Rie Motoki; Kotaro Hama; Shinichi Okudaira; Mayuko Ishida; Hideo Ogiso; Masayuki Tanaka; Norio Matsuki; Ryo Taguchi; Motomu Kanai; Masakatsu Shibasaki; Hiroyuki Arai; Junken Aoki
Journal:  J Biochem       Date:  2009-05-04       Impact factor: 3.387

Review 8.  Graft-versus-leukemia effects of transplantation and donor lymphocytes.

Authors:  Hans-Jochem Kolb
Journal:  Blood       Date:  2008-12-01       Impact factor: 22.113

9.  High-frequency and adaptive-like dynamics of human CD1 self-reactive T cells.

Authors:  Claudia de Lalla; Marco Lepore; Francesco M Piccolo; Anna Rinaldi; Andrea Scelfo; Claudio Garavaglia; Lucia Mori; Gennaro De Libero; Paolo Dellabona; Giulia Casorati
Journal:  Eur J Immunol       Date:  2011-01-18       Impact factor: 5.532

10.  A novel self-lipid antigen targets human T cells against CD1c(+) leukemias.

Authors:  Marco Lepore; Claudia de Lalla; S Ramanjaneyulu Gundimeda; Heiko Gsellinger; Michela Consonni; Claudio Garavaglia; Sebastiano Sansano; Francesco Piccolo; Andrea Scelfo; Daniel Häussinger; Daniela Montagna; Franco Locatelli; Chiara Bonini; Attilio Bondanza; Alessandra Forcina; Zhiyuan Li; Guanghui Ni; Fabio Ciceri; Paul Jenö; Chengfeng Xia; Lucia Mori; Paolo Dellabona; Giulia Casorati; Gennaro De Libero
Journal:  J Exp Med       Date:  2014-06-16       Impact factor: 14.307
  10 in total
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Review 1.  Lipids hide or step aside for CD1-autoreactive T cell receptors.

Authors:  Rachel N Cotton; Adam Shahine; Jamie Rossjohn; D Branch Moody
Journal:  Curr Opin Immunol       Date:  2018-05-05       Impact factor: 7.486

Review 2.  Phospholipid signaling in innate immune cells.

Authors:  Valerie B O'Donnell; Jamie Rossjohn; Michael Jo Wakelam
Journal:  J Clin Invest       Date:  2018-04-23       Impact factor: 14.808

3.  Melanomas and Dysplastic Nevi Differ in Epidermal CD1c+ Dendritic Cell Count.

Authors:  Grzegorz Dyduch; Katarzyna Ewa Tyrak; Anna Glajcar; Joanna Szpor; Magdalena Ulatowska-Białas; Krzysztof Okoń
Journal:  Biomed Res Int       Date:  2017-02-26       Impact factor: 3.411

Review 4.  Casting a wider net: Immunosurveillance by nonclassical MHC molecules.

Authors:  M Patricia D'Souza; Erin Adams; John D Altman; Michael E Birnbaum; Cesar Boggiano; Giulia Casorati; Yueh-Hsiu Chien; Anthony Conley; Sidonia Barbara Guiomar Eckle; Klaus Früh; Timothy Gondré-Lewis; Namir Hassan; Huang Huang; Lakshmi Jayashankar; Anne G Kasmar; Nina Kunwar; Judith Lavelle; David M Lewinsohn; Branch Moody; Louis Picker; Lakshmi Ramachandra; Nilabh Shastri; Peter Parham; Andrew J McMichael; Jonathan W Yewdell
Journal:  PLoS Pathog       Date:  2019-02-21       Impact factor: 6.823

Review 5.  Proceedings From the First International Workshop at Sidra Medicine: "Engineered Immune Cells in Cancer Immunotherapy (EICCI): From Discovery to Off-the-Shelf Development", 15th-16th February 2019, Doha, Qatar.

Authors:  Bella Guerrouahen; Muhammad Elnaggar; Anjud Al-Mohannadi; Dhanya Kizhakayil; Chiara Bonini; Reuben Benjamin; Renier Brentjens; Christian J Buchholz; Giulia Casorati; Soldano Ferrone; Frederick L Locke; Francisco Martin; Axel Schambach; Cameron Turtle; Paul Veys; Hans J van der Vliet; Cristina Maccalli
Journal:  Front Immunol       Date:  2021-01-14       Impact factor: 7.561

6.  CD207+/langerin positive dendritic cells in invasive and in situ cutaneous malignant melanoma.

Authors:  Grzegorz Dyduch; Katarzyna E Tyrak; Anna Glajcar; Joanna Szpor; Krzysztof Okoń
Journal:  Postepy Dermatol Alergol       Date:  2017-05-29       Impact factor: 1.837

7.  Does CD1a Expression Influence T Cell Function in Patients With Langerhans Cell Histiocytosis?

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Journal:  Front Immunol       Date:  2021-12-10       Impact factor: 7.561
  7 in total

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