Mouna Kallel1, Fatma Elloumi1, Abdelmajid Khabir2, Lilia Ghorbal1, Souhir Chaabouni1, Habib Amouri3, Mounir Frikha2, Jamel Daoud4. 1. Department of Oncology and Radiotherapy, Habib Bourguiba University Hospital, Ain Street km 0.5, Sfax 3000, Tunisia. 2. Department of Oncology and Radiotherapy, Habib Bourguiba University Hospital, Ain Street km 0.5, Sfax 3000, Tunisia ; Cytology and Pathology, Habib Bourguiba University Hospital, Sfax, Tunisia. 3. Department of Oncology and Radiotherapy, Habib Bourguiba University Hospital, Ain Street km 0.5, Sfax 3000, Tunisia ; Gynecology and Obstetric, Hedi Chaker University Hospital, Ain Street km 0.5, Sfax 3000, Tunisia. 4. Department of Oncology and Radiotherapy, Habib Bourguiba University Hospital, Ain Street km 0.5, Sfax 3000, Tunisia ; Medical Oncology, Habib Bourguiba University Hospital, Sfax, Tunisia.
Abstract
PURPOSE: To define epidemiological, clinical, therapeutic and prognostic factors influencing survival of breast cancer in young women younger than 35 in southern Tunisia. MATERIAL AND METHODS: This is a retrospective study of 83 patients younger than 35 years and treated within tumors mammary committee of Sfax. RESULTS: The mean age was 31.7 years. T2 stage, high grade with positive node tumors were frequent. Breast surgery was performed for 73 patients. Chemotherapy was neo-adjuvant, adjuvant and palliative for respectively 10, 62 and 13 patients. Radiotherapy was delivered for 65 patients with curative intent and for 8 metastatic patients. Endocrine therapy was adjuvant in 38 patients and palliative in 6 cases. The overall survival (OS) at 5 years was 66.8%. Pejorative prognostic factors in uni-variate analysis were clinical T stage (T3, T4), and the number of involved lymph nodes. CONCLUSION: Despite adequate treatment, the prognosis of breast cancer in young women remains worse. Early diagnosis is necessary to promote outcome.
PURPOSE: To define epidemiological, clinical, therapeutic and prognostic factors influencing survival of breast cancer in young women younger than 35 in southern Tunisia. MATERIAL AND METHODS: This is a retrospective study of 83 patients younger than 35 years and treated within tumors mammary committee of Sfax. RESULTS: The mean age was 31.7 years. T2 stage, high grade with positive node tumors were frequent. Breast surgery was performed for 73 patients. Chemotherapy was neo-adjuvant, adjuvant and palliative for respectively 10, 62 and 13 patients. Radiotherapy was delivered for 65 patients with curative intent and for 8 metastatic patients. Endocrine therapy was adjuvant in 38 patients and palliative in 6 cases. The overall survival (OS) at 5 years was 66.8%. Pejorative prognostic factors in uni-variate analysis were clinical T stage (T3, T4), and the number of involved lymph nodes. CONCLUSION: Despite adequate treatment, the prognosis of breast cancer in young women remains worse. Early diagnosis is necessary to promote outcome.
Entities:
Keywords:
Breast; Cancer; Clinical; Prognosis; Young women
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