Literature DB >> 2594904

A comparison of calcium antagonists and diazepam in reducing ethanol withdrawal tremors.

G H Bone1, E Majchrowicz, P R Martin, M Linnoila, D J Nutt.   

Abstract

The calcium antagonists nimodipine and dantrolene were compared with diazepam in an animal model of tolerance and physical dependence upon ethanol. Nimodipine and dantrolene were both effective in suppressing withdrawal tremors but diazepam was clearly superior to both agents. These results suggest that the ethanol withdrawal syndrome is only partially mediated by increased calcium flux.

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Year:  1989        PMID： 2594904     DOI： 10.1007/bf00445563

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  14 in total

1.  Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists.

Authors:  M C Sanguinetti; R S Kass
Journal:  Circ Res       Date:  1984-09       Impact factor: 17.367

2.  Suppression by 1,3-butanediol of the ethanol withdrawal syndrome in rats.

Authors:  E Majchrowicz; W A Hunt; C Piantadosi
Journal:  Science       Date:  1976-12-10       Impact factor: 47.728

3.  Induction of physical dependence upon ethanol and the associated behavioral changes in rats.

Authors:  E Majchrowicz
Journal:  Psychopharmacologia       Date:  1975-09-17

4.  Calcium channel antagonists decrease the ethanol withdrawal syndrome.

Authors:  H J Little; S J Dolin; M J Halsey
Journal:  Life Sci       Date:  1986-12-01       Impact factor: 5.037

5.  Calcium channel antagonist binding sites labeled by 3H-nimodipine in human brain.

Authors:  S J Peroutka; G S Allen
Journal:  J Neurosurg       Date:  1983-12       Impact factor: 5.115

6.  Nimodipine's interactions with other drugs: I. Ethanol.

Authors:  R L Isaacson; J C Molina; L J Draski; J E Johnston
Journal:  Life Sci       Date:  1985-06-10       Impact factor: 5.037

7.  Behavioral effects of nimodipine in animals.

Authors:  F Hoffmeister; U Benz; A Heise; H P Krause; V Neuser
Journal:  Arzneimittelforschung       Date:  1982

8.  Possible association of alcohol tolerance with increased synaptic Ca2+ sensitivity.

Authors:  M A Lynch; J M Littleton
Journal:  Nature       Date:  1983 May 12-18       Impact factor: 49.962

9.  Dihydropyridine receptor in rat brain labeled with [3H]nimodipine.

Authors:  P Bellemann; A Schade; R Towart
Journal:  Proc Natl Acad Sci U S A       Date:  1983-04       Impact factor: 11.205

10.  Increased dihydropyridine-sensitive calcium channels in rat brain may underlie ethanol physical dependence.

Authors:  S Dolin; H Little; M Hudspith; C Pagonis; J Littleton
Journal:  Neuropharmacology       Date:  1987 Feb-Mar       Impact factor: 5.250
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  8 in total

Review 1.  Psychopharmacological properties of calcium channel inhibitors.

Authors:  O Pucilowski
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

2.  Differential effects of L-type calcium channel blockers and stimulants on naloxone-precipitated withdrawal in mice acutely dependent on morphine.

Authors:  M Barrios; J M Baeyens
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

Review 3.  Neurochemical mechanisms of alcohol withdrawal.

Authors:  Howard C Becker; Patrick J Mulholland
Journal:  Handb Clin Neurol       Date:  2014

Review 4.  Novel therapeutic strategies for alcohol and drug addiction: focus on GABA, ion channels and transcranial magnetic stimulation.

Authors:  Giovanni Addolorato; Lorenzo Leggio; F Woodward Hopf; Marco Diana; Antonello Bonci
Journal:  Neuropsychopharmacology       Date:  2011-10-26       Impact factor: 7.853

5.  Action of chlormethiazole in a model of ethanol withdrawal.

Authors:  A R Green; E M Davies; H J Little; M A Whittington; A J Cross
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

Review 6.  Neurologic effects of alcoholism.

Authors:  I Diamond; R O Messing
Journal:  West J Med       Date:  1994-09

7.  Facilitation of shuttle-box avoidance behaviour in mice treated with nifedipine in combination with amphetamine.

Authors:  J Vetulani; M Battaglia; C Castellano; M Sansone
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

8.  Diazepam prevents progression of kindled alcohol withdrawal behaviour.

Authors:  J Ulrichsen; B Bech; P Allerup; R Hemmingsen
Journal:  Psychopharmacology (Berl)       Date:  1995-10       Impact factor: 4.530
  8 in total

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