Literature DB >> 2594689

Near-infrared spectroscopic determination of residual moisture in lyophilized sucrose through intact glass vials.

M S Kamat1, R A Lodder, P P DeLuca.   

Abstract

A rapid, noninvasive, and nondestructive method for determining moisture in sealed freeze-drying vials is described. The method, based on near-infrared spectrometry, used a novel fiber-optic diffuse-reflectance probe to make remote reflectance measurements from 1100 to 2500 nm through the bottom of glass vials. The correlation of the method to results obtained by Karl Fischer analysis was good (r2 = 0.97). The moisture content of sucrose, a common cryoprotectant, was determined with an error of 0.27% using a single sample scan.

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Year:  1989        PMID： 2594689     DOI： 10.1023/a:1015997530367

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  5 in total

1.  Thermal decomposition of amorphous beta-lactam antibacterials.

Authors:  M J Pikal; A L Lukes; J E Lang
Journal:  J Pharm Sci       Date:  1977-09       Impact factor: 3.534

2.  Titration of residual moisture in lyophilized vials.

Authors:  E E Theimer; J J Pavelek
Journal:  J Pharm Sci       Date:  1968-05       Impact factor: 3.534

3.  Pharmaceutical applications of the near infrared determination of water.

Authors:  J E Sinsheimer; N M Poswalk
Journal:  J Pharm Sci       Date:  1968-11       Impact factor: 3.534

4.  Lyophilization of sincalide and correlation of headspace relative humidity with product stability.

Authors:  R C Huber; A O Niedermayer; A L Weiss
Journal:  J Pharm Sci       Date:  1978-09       Impact factor: 3.534

5.  Estimation of the degree of crystallinity of cefazolin sodium by X-ray and infrared methods.

Authors:  M S Kamat; T Osawa; R J DeAngelis; Y Koyama; P P DeLuca
Journal:  Pharm Res       Date:  1988-07       Impact factor: 4.200
  5 in total
  9 in total

1.  In-situ near-infrared spectroscopy monitoring of the lyophilization process.

Authors:  Mikael Brülls; Staffan Folestad; Anders Sparén; Anders Rasmuson
Journal:  Pharm Res       Date:  2003-03       Impact factor: 4.200

2.  Evaluation of the conformity index and the Mahalanobis distance as a tool for process analysis: a technical note.

Authors:  Gary E Ritchie; Howard Mark; Emil W Ciurczak
Journal:  AAPS PharmSciTech       Date:  2003       Impact factor: 3.246

Review 3.  Design of freeze-drying processes for pharmaceuticals: practical advice.

Authors:  Xiaolin Tang; Michael J Pikal
Journal:  Pharm Res       Date:  2004-02       Impact factor: 4.200

4.  Spectrophotometric prediction of the dissolution rate of carbamazepine tablets.

Authors:  P N Zannikos; W I Li; J K Drennen; R A Lodder
Journal:  Pharm Res       Date:  1991-08       Impact factor: 4.200

5.  Near-infrared spectroscopy as a nondestructive alternative to conventional tablet hardness testing.

Authors:  K M Morisseau; C T Rhodes
Journal:  Pharm Res       Date:  1997-01       Impact factor: 4.200

6.  Determination of extent of formaldehyde-induced crosslinking in hard gelatin capsules by near-infrared spectrophotometry.

Authors:  T B Gold; R G Buice; R A Lodder; G A Digenis
Journal:  Pharm Res       Date:  1997-08       Impact factor: 4.200

7.  On-line moisture detection for a microwave vacuum dryer.

Authors:  J G White
Journal:  Pharm Res       Date:  1994-05       Impact factor: 4.200

8.  Near-infrared (NIR) monitoring of H2O2 vapor concentration during vapor hydrogen peroxide (VHP) sterilisation.

Authors:  S Corveleyn; G M Vandenbossche; J P Remon
Journal:  Pharm Res       Date:  1997-03       Impact factor: 4.200

Review 9.  Process Analytical Technology Tools for Monitoring Pharmaceutical Unit Operations: A Control Strategy for Continuous Process Verification.

Authors:  Eun Ji Kim; Ji Hyeon Kim; Min-Soo Kim; Seong Hoon Jeong; Du Hyung Choi
Journal:  Pharmaceutics       Date:  2021-06-21       Impact factor: 6.321
  9 in total

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