David Fuks1,2,3,4, Pierre Duhaut2,4, Francois Mauvais5, Marc Pocard6, Vincent Haccart7, Jean-Christophe Paquet8, Bertrand Millat9, Simon Msika10, Igor Sielezneff11, Michel Scotté12, Denis Chatelain13, Jean Marc Regimbeau1,3. 1. Department of Digestive Surgery, Amiens University Hospital, Amiens, France. 2. Department of Internal Medicine, Amiens University Hospital, Amiens, France. 3. Inserm U1088, Faculté de Médecine, Université de Picardie Jules Verne, Amiens, France. 4. Réseau d'Epidémiologie Clinique International Francophone, Amiens University Hospital, Amiens, France. 5. Department of Digestive Surgery, Beauvais Hospital, Beauvais, France. 6. Department of Digestive Surgery, Lariboisière University Hospital, Paris, France. 7. Department of Digestive Surgery, Montreuil-sur-Mer Hospital, Rang-du-Fliers, France. 8. Department of Digestive Surgery, Longjumeau Hospital, Longjumeau, France. 9. Department of Digestive Surgery, Montpellier University Hospital, Montpellier, France. 10. Department of Digestive Surgery, Louis Mourier Hospital, Colombes, France. 11. Department of Digestive Surgery, La Timone University Hospital, Marseille, France. 12. Department of Digestive Surgery, Rouen University Hospital, Rouen Cedex, France. 13. Department of Pathology, Amiens University Hospital, Amiens, France.
Abstract
OBJECTIVES: To compare the demographic characteristics and intra- and postoperative outcomes in elderly adults (≥75) with those of younger adults undergoing early (<5 days after onset of complaints) cholecystectomy. DESIGN:Retrospective analysis from May 2010 to August 2012. SETTING: Randomized, multicenter, clinical trial (ABCAL Study, NCT01015417). PARTICIPANTS: Individuals with mild or moderate acute calculous cholecystitis (ACC) according to the Tokyo Guidelines (N=414; n=78 aged 75-94, median 82; n=336 aged 18-74, median 49). MEASUREMENTS: Demographic characteristics and pre-, intra-, and postoperative data. RESULTS: The elderly group was more likely to have an American Society of Anesthesiologists score of 3 or greater (62% vs 23%, P<.001), higher serum creatinine (103 vs 74 μmol/L, P<.001), and more-severe ACC (moderate ACC (62% vs 50%, P=.05), gangrenous cholecystitis (38% vs 15%, P=.001)) on preoperative imaging and confirmed intraoperatively. Ulcerated mucosa (76% vs 61%, P=.001) was significantly more frequent in the elderly group. Operative time, postoperative mortality, and postoperative infectious (18% vs 14%, P=.35) and noninfectious (9% vs 3%, P=.80) complications were similar between the two groups. Median length of stay (7.0 vs 5.0 days, P=.54) and readmission rate (15% vs 4%, P=.07) were not significantly higher in the elderly group. No significant difference was observed for the subgroup of participants aged 80 and older. CONCLUSION: In this randomized trial that included a selected sample of older adults, there was no difference in major outcomes between elderly adults and their younger counterparts after early cholecystectomy. The findings are limited because important geriatric outcomes such as delirium and functional decline were not examined.
RCT Entities:
OBJECTIVES: To compare the demographic characteristics and intra- and postoperative outcomes in elderly adults (≥75) with those of younger adults undergoing early (<5 days after onset of complaints) cholecystectomy. DESIGN: Retrospective analysis from May 2010 to August 2012. SETTING: Randomized, multicenter, clinical trial (ABCAL Study, NCT01015417). PARTICIPANTS: Individuals with mild or moderate acute calculous cholecystitis (ACC) according to the Tokyo Guidelines (N=414; n=78 aged 75-94, median 82; n=336 aged 18-74, median 49). MEASUREMENTS: Demographic characteristics and pre-, intra-, and postoperative data. RESULTS: The elderly group was more likely to have an American Society of Anesthesiologists score of 3 or greater (62% vs 23%, P<.001), higher serum creatinine (103 vs 74 μmol/L, P<.001), and more-severe ACC (moderate ACC (62% vs 50%, P=.05), gangrenous cholecystitis (38% vs 15%, P=.001)) on preoperative imaging and confirmed intraoperatively. Ulcerated mucosa (76% vs 61%, P=.001) was significantly more frequent in the elderly group. Operative time, postoperative mortality, and postoperative infectious (18% vs 14%, P=.35) and noninfectious (9% vs 3%, P=.80) complications were similar between the two groups. Median length of stay (7.0 vs 5.0 days, P=.54) and readmission rate (15% vs 4%, P=.07) were not significantly higher in the elderly group. No significant difference was observed for the subgroup of participants aged 80 and older. CONCLUSION: In this randomized trial that included a selected sample of older adults, there was no difference in major outcomes between elderly adults and their younger counterparts after early cholecystectomy. The findings are limited because important geriatric outcomes such as delirium and functional decline were not examined.
Authors: Sivesh K Kamarajah; Santhosh Karri; James R Bundred; Richard P T Evans; Aaron Lin; Tania Kew; Chinenye Ekeozor; Susan L Powell; Pritam Singh; Ewen A Griffiths Journal: Surg Endosc Date: 2020-07-13 Impact factor: 4.584