| Literature DB >> 25946312 |
Anja K Holzer1, Katharina Hiebler1, Francesco G Mutti1, Robert C Simon1, Lars Lauterbach2, Oliver Lenz2, Wolfgang Kroutil1.
Abstract
A biocatalytic system is presented for the stereoselective amination of ketones at the expense of NH3 and molecular hydrogen. By using a NAD(+)-reducing hydrogenase, an alanine dehydrogenase, and a suitable ω-transaminase, the R- as well as the S-enantiomer of various amines could be prepared with up to >99% ee and 98% conversion.Entities:
Mesh：
Substances：
Year: 2015 PMID： 25946312 DOI： 10.1021/acs.orglett.5b01154
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005