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Literature DB >> 2594595

Effect of treatment with botulinum toxin on spasticity.

Abstract

Botulinum toxin, a product of Clostridium botulinum, produces presynaptic neuromuscular block by preventing release of acetylcholine from nerve endings. The toxin was injected directly into the skeletal muscles of six patients with severe spasticity due to stroke-related hemiplegia. It produced both subjective and objective improvement. The toxin injections were well tolerated and no significant side effect was reported.

Entities: Chemical Disease Species

Mesh：

Substances：
Botulinum Toxins

Year: 1989 PMID： 2594595 PMCID： PMC2429289 DOI： 10.1136/pgmj.65.762.208

Source DB: PubMed Journal: Postgrad Med J ISSN： 0032-5473 Impact factor: 2.401

10 in total

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Journal: Md State Med J Date: 1965-02

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Authors: B Goff
Journal: Physiotherapy Date: 1976-11 Impact factor: 3.358

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Authors: M F Brin; S Fahn; C Moskowitz; A Friedman; H M Shale; P E Greene; A Blitzer; T List; D Lange; R E Lovelace
Journal: Adv Neurol Date: 1988

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Journal: Arch Neurol Date: 1974-10

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Authors: J K Tsui; A Eisen; A J Stoessl; S Calne; D B Calne
Journal: Lancet Date: 1986-08-02 Impact factor: 79.321

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Authors: I Kao; D B Drachman; D L Price
Journal: Science Date: 1976-09-24 Impact factor: 47.728

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Authors: A B Scott
Journal: Ophthalmology Date: 1980-10 Impact factor: 12.079

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Authors: C V Granger; L S Dewis; N C Peters; C C Sherwood; J E Barrett
Journal: Arch Phys Med Rehabil Date: 1979-01 Impact factor: 3.966

9. Long-term results of treatment of idiopathic blepharospasm with botulinum toxin injections.

Authors: J S Elston
Journal: Br J Ophthalmol Date: 1987-09 Impact factor: 4.638

10. Effect of treatment with botulinum toxin on neurogenic blepharospasm.

Authors: J S Elston; R W Russell
Journal: Br Med J (Clin Res Ed) Date: 1985-06-22

10 in total

18 in total

1. Evaluating the role of botulinum toxin in the management of focal hypertonia in adults.

Authors: D Richardson; G Sheean; D Werring; M Desai; S Edwards; R Greenwood; A Thompson
Journal: J Neurol Neurosurg Psychiatry Date: 2000-10 Impact factor: 10.154

Review 2. Spasticity after stroke. Epidemiology and optimal treatment.

Authors: C F O'Brien; L C Seeberger; D B Smith
Journal: Drugs Aging Date: 1996-11 Impact factor: 3.923

3. Impact of botulinum toxin type A on disability and carer burden due to arm spasticity after stroke: a randomised double blind placebo controlled trial.

Authors: B B Bhakta; J A Cozens; M A Chamberlain; J M Bamford
Journal: J Neurol Neurosurg Psychiatry Date: 2000-08 Impact factor: 10.154

4. Use of botulinum toxin in stroke patients with severe upper limb spasticity.

Authors: B B Bhakta; J A Cozens; J M Bamford; M A Chamberlain
Journal: J Neurol Neurosurg Psychiatry Date: 1996-07 Impact factor: 10.154

5. Botulinum toxin (Dysport) treatment of hip adductor spasticity in multiple sclerosis: a prospective, randomised, double blind, placebo controlled, dose ranging study.

Authors: N Hyman; M Barnes; B Bhakta; A Cozens; M Bakheit; B Kreczy-Kleedorfer; W Poewe; J Wissel; P Bain; S Glickman; A Sayer; A Richardson; C Dott
Journal: J Neurol Neurosurg Psychiatry Date: 2000-06 Impact factor: 10.154