Joshua R Hummel1, Jonathan A Ellman1. 1. Department of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520-8107, United States.
Abstract
The first examples of cobalt(III)-catalyzed C-H bond addition to isocyanates are described, providing a convergent strategy for arene and heteroarene amidation. Using a robust air- and moisture-stable catalyst, this transformation demonstrates a broad isocyanate scope and good functional-group compatibility and has been performed on gram scale.
The first examples of cobalt(III)-catalyzed C-H bond addition to n class="Chemical">isocyanates are described, providing a convergent strategy for arene and heteroarene amidation. Using a robust air- and moisture-stable catalyst, this transformation demonstrates a broad isocyanate scope and good functional-group compatibility and has been performed on gram scale.
Authors: Jihye Park; Eonjeong Park; Aejin Kim; Youngil Lee; Ki-Whan Chi; Jong Hwan Kwak; Young Hoon Jung; In Su Kim Journal: Org Lett Date: 2011-07-27 Impact factor: 6.005