Literature DB >> 25945137

Effects of hydraulic pressure on cardiomyoblasts in a microfluidic device.

Yu-Fang Hsiao, Huei-Jyuan Pan1, Yi-Chung Tung1, Chien-Chang Chen2, Chau-Hwang Lee.   

Abstract

We employed a microfluidic device to study the effects of hydraulic pressure on cardiomyoblast H9c2. The 170 mm Hg pressure increased the cellular area and the expression of atrial natriuretic peptide. With the same device, we demonstrated that the effects of hydraulic pressure on the cardiomyoblast could be reduced by the inhibitor of focal adhesion kinase. This mechanical-chemical antagonism could lead to a potential therapeutic strategy of hypertension-induced cardiac hypertrophy.

Entities:  

Year:  2015        PMID： 25945137      PMCID： PMC4393411          DOI： 10.1063/1.4917080

Source DB:  PubMed          Journal:  Biomicrofluidics        ISSN： 1932-1058            Impact factor:   2.800


  28 in total

Review 1.  Myofibroblasts and mechano-regulation of connective tissue remodelling.

Authors:  James J Tomasek; Giulio Gabbiani; Boris Hinz; Christine Chaponnier; Robert A Brown
Journal:  Nat Rev Mol Cell Biol       Date:  2002-05       Impact factor: 94.444

Review 2.  Cardiac plasticity.

Authors:  Joseph A Hill; Eric N Olson
Journal:  N Engl J Med       Date:  2008-03-27       Impact factor: 91.245

3.  Stretching cardiac myocytes stimulates protooncogene expression.

Authors:  I Komuro; T Kaida; Y Shibazaki; M Kurabayashi; Y Katoh; E Hoh; F Takaku; Y Yazaki
Journal:  J Biol Chem       Date:  1990-03-05       Impact factor: 5.157

Review 4.  Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies.

Authors:  Bianca C Bernardo; Kate L Weeks; Lynette Pretorius; Julie R McMullen
Journal:  Pharmacol Ther       Date:  2010-05-12       Impact factor: 12.310

5.  Modulating chemotaxis of lung cancer cells by using electric fields in a microfluidic device.

Authors:  Yu-Chiu Kao; Meng-Hua Hsieh; Chung-Chun Liu; Huei-Jyuan Pan; Wei-Yu Liao; Ji-Yen Cheng; Po-Ling Kuo; Chau-Hwang Lee
Journal:  Biomicrofluidics       Date:  2014-04-01       Impact factor: 2.800

6.  Cyclic mechanical stretch induces cardiomyocyte orientation and polarization of the gap junction protein connexin43.

Authors:  Aida Salameh; Anne Wustmann; Sebastian Karl; Katja Blanke; Daniel Apel; Diana Rojas-Gomez; Heike Franke; Friedrich W Mohr; Jan Janousek; Stefan Dhein
Journal:  Circ Res       Date:  2010-04-08       Impact factor: 17.367

7.  Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study.

Authors:  D Levy; R J Garrison; D D Savage; W B Kannel; W P Castelli
Journal:  N Engl J Med       Date:  1990-05-31       Impact factor: 91.245

8.  Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A.

Authors:  Rita Holtwick; Martin van Eickels; Boris V Skryabin; Hideo A Baba; Alexander Bubikat; Frank Begrow; Michael D Schneider; David L Garbers; Michaela Kuhn
Journal:  J Clin Invest       Date:  2003-05       Impact factor: 14.808

9.  'Pressure-flow'-triggered intracellular Ca2+ transients in rat cardiac myocytes: possible mechanisms and role of mitochondria.

Authors:  Stephen Belmonte; Martin Morad
Journal:  J Physiol       Date:  2008-01-10       Impact factor: 5.182

10.  Focal adhesion kinase is activated and mediates the early hypertrophic response to stretch in cardiac myocytes.

Authors:  Adriana S Torsoni; Sabata S Constancio; Wilson Nadruz; Steven K Hanks; Kleber G Franchini
Journal:  Circ Res       Date:  2003-06-12       Impact factor: 17.367
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