Literature DB >> 25944019

Adherence to Metformin, Statins, and ACE/ARBs Within the Diabetes Health Plan (DHP).

O Kenrik Duru1, Norman Turk2, Susan L Ettner2,3, Romain Neugebauer4, Tannaz Moin5,6, Jinnan Li2, Lindsay Kimbro2, Charles Chan7, Robert H Luchs7, Abigail M Keckhafer7, Anya Kirvan7, Sam Ho7, Carol M Mangione2,3.   

Abstract

BACKGROUND: Reducing patient cost-sharing and engaging patients in disease management activities have been shown to increase uptake of evidence-based care.
OBJECTIVE: To evaluate the effect of employer purchase of a disease-specific plan with reduced cost-sharing and disease management (the Diabetes Health Plan/DHP) on medication adherence among eligible employees and dependents.
DESIGN: Employer-level "intent to treat" cohort study, including data from eligible employees and their dependents with diabetes, regardless of whether they were enrolled in the DHP.
SETTING: Employers that contracted with a large national health plan administrator in 2009, 2010, and/or 2011. PARTICIPANTS: Ten employers that purchased the DHP and 191 employers that did not (controls). Inverse probability weighting (IPW) estimation was used to adjust for inter-group differences. INTERVENTION: The DHP includes free or low-cost medications and physician visits. Enrollment strategies and specific benefit designs are determined by the employer and vary in practice. DHP participants are notified up front that they must engage in their own health care (e.g., receiving diabetes-related screening) in order to remain enrolled. MAIN OUTCOME MEASURE: Mean employee adherence to metformin, statins, and ACE/ARBs at the employer level at one year post-DHP implementation, as measured by the proportion of days covered (PDC).
RESULTS: Baseline adherence to the three medications was similar across DHP and control employers, ranging from 64 to 69 %. In the first year after DHP implementation, predicted employer-level adherence for metformin (+4.9 percentage points, p = 0.017), statins (+4.8, p = 0.019), and ACE/ARBs (+4.4, p = 0.02) was higher with DHP purchase. LIMITATIONS: Non-randomized, observational study.
CONCLUSIONS: The Diabetes Health Plan, an innovative health plan that combines reduced cost-sharing and disease management with an up-front requirement of enrollee participation in his or her own health care, is associated with a modest improvement in medication adherence at 12 months.

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Year:  2015        PMID: 25944019      PMCID: PMC4617948          DOI: 10.1007/s11606-015-3284-8

Source DB:  PubMed          Journal:  J Gen Intern Med        ISSN: 0884-8734            Impact factor:   5.128


  13 in total

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2.  Using inverse probability-weighted estimators in comparative effectiveness analyses with observational databases.

Authors:  Lesley H Curtis; Bradley G Hammill; Eric L Eisenstein; Judith M Kramer; Kevin J Anstrom
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3.  Workplace wellness programs can generate savings.

Authors:  Katherine Baicker; David Cutler; Zirui Song
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4.  Greater adherence to diabetes drugs is linked to less hospital use and could save nearly $5 billion annually.

Authors:  Ashish K Jha; Ronald E Aubert; Jianying Yao; J Russell Teagarden; Robert S Epstein
Journal:  Health Aff (Millwood)       Date:  2012-08       Impact factor: 6.301

5.  Prespecified falsification end points: can they validate true observational associations?

Authors:  Vinay Prasad; Anupam B Jena
Journal:  JAMA       Date:  2013-01-16       Impact factor: 56.272

6.  A value-based insurance design program at a large company boosted medication adherence for employees with chronic illnesses.

Authors:  Teresa B Gibson; Sara Wang; Emily Kelly; Candace Brown; Christine Turner; Feride Frech-Tamas; Joseph Doyle; Edward Mauceri
Journal:  Health Aff (Millwood)       Date:  2011-01       Impact factor: 6.301

7.  Optimizing enrollment in employer health programs: a comparison of enrollment strategies in the Diabetes Health Plan.

Authors:  Lindsay B Kimbro; Jinnan Li; Norman Turk; Susan L Ettner; Tannaz Moin; Carol M Mangione; O Kenrik Duru
Journal:  Am J Manag Care       Date:  2014-08-01       Impact factor: 2.229

8.  Impact of medication adherence on absenteeism and short-term disability for five chronic diseases.

Authors:  Ginger S Carls; M Christopher Roebuck; Troyen A Brennan; Julie A Slezak; Olga S Matlin; Teresa B Gibson
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Review 9.  Medication adherence: its importance in cardiovascular outcomes.

Authors:  P Michael Ho; Chris L Bryson; John S Rumsfeld
Journal:  Circulation       Date:  2009-06-16       Impact factor: 29.690

10.  Evaluation of the diabetes health plan to improve diabetes care and prevention.

Authors:  O Kenrik Duru; Carol M Mangione; Charles Chan; Abigail Keckhafer; Lindsay Kimbro; K Anya Kirvan; Norman Turk; Robert Luchs; Jinnan Li; Susan Ettner
Journal:  Prev Chronic Dis       Date:  2013       Impact factor: 2.830

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  10 in total

1.  Capsule Commentary on Duru et al., Adherence to Metformin, Statins, and ACE/ARBs Within the Diabetes Health Plan (DHP).

Authors:  R Brett McQueen
Journal:  J Gen Intern Med       Date:  2015-11       Impact factor: 5.128

Review 2.  Advancing Health Policy and Program Research in Diabetes: Findings from the Natural Experiments for Translation in Diabetes (NEXT-D) Network.

Authors:  Mohammed K Ali; Frank Wharam; O Kenrik Duru; Julie Schmittdiel; Ronald T Ackermann; Jeanine Albu; Dennis Ross-Degnan; Christine M Hunter; Carol Mangione; Edward W Gregg
Journal:  Curr Diab Rep       Date:  2018-11-20       Impact factor: 4.810

3.  High-Deductible Insurance and Delay in Care for the Macrovascular Complications of Diabetes.

Authors:  J Frank Wharam; Christine Y Lu; Fang Zhang; Matthew Callahan; Xin Xu; Jamie Wallace; Stephen Soumerai; Dennis Ross-Degnan; Joseph P Newhouse
Journal:  Ann Intern Med       Date:  2018-11-20       Impact factor: 25.391

4.  Financial Incentives and Diabetes Disease Control in Employees: A Retrospective Cohort Analysis.

Authors:  Anita D Misra-Hebert; Bo Hu; Glen Taksler; Robert Zimmerman; Michael B Rothberg
Journal:  J Gen Intern Med       Date:  2016-04-11       Impact factor: 5.128

5.  Evaluation of drug interactions between fimasartan and rosuvastatin after single and multiple doses in healthy Caucasians.

Authors:  Jieon Lee; Su-Jin Rhee; SeungHwan Lee; Kyung-Sang Yu
Journal:  Drug Des Devel Ther       Date:  2018-04-06       Impact factor: 4.162

6.  Effect of Cost and Formulation on Persistence and Adherence to Initial Metformin Therapy for Type 2 Diabetes.

Authors:  James H Flory; Alvin I Mushlin
Journal:  Diabetes Care       Date:  2020-04-06       Impact factor: 19.112

7.  Association of the Diabetes Health Plan with emergency room and inpatient hospital utilization: a Natural Experiment for Translation in Diabetes (NEXT-D) Study.

Authors:  Tannaz Moin; Neil Steers; Susan L Ettner; Kenrik Duru; Norman Turk; Charles Chan; Abigail M Keckhafer; Robert H Luchs; Sam Ho; Carol M Mangione
Journal:  BMJ Open Diabetes Res Care       Date:  2021-01

Review 8.  Introductory Overview of the Natural Experiments for Translation in Diabetes 2.0 (NEXT-D2) Network: Examining the Impact of US Health Policies and Practices to Prevent Diabetes and Its Complications.

Authors:  O Kenrik Duru; Carol M Mangione; Hector P Rodriguez; Dennis Ross-Degnan; J Frank Wharam; Bernard Black; Abel Kho; Nathalie Huguet; Heather Angier; Victoria Mayer; David Siscovick; Jennifer L Kraschnewski; Lizheng Shi; Elizabeth Nauman; Edward W Gregg; Mohammed K Ali; Pamela Thornton; Steven Clauser
Journal:  Curr Diab Rep       Date:  2018-02-05       Impact factor: 4.810

9.  Results from NEXT-D: the association of a pre-diabetes-specific health plan and rates of incident diabetes among a national sample of working-age adults.

Authors:  Tannaz Moin; Jinnan Li; Kenrik Duru; Susan L Ettner; Norman Turk; Charles Chan; Abigail M Keckhafer; Robert H Luchs; Sam Ho; Carol M Mangione
Journal:  BMJ Open Diabetes Res Care       Date:  2020-04

10.  Compared to commercially insured patients, Medicare advantage patients adopt newer diabetes drugs more slowly and adhere to them less.

Authors:  James H Flory; Jing Li; Ghadeer K Dawwas; Charles E Leonard
Journal:  Endocrinol Diabetes Metab       Date:  2021-04-02
  10 in total

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