| Literature DB >> 25943420 |
Barbara Sottero1, Simona Gargiulo1, Isabella Russo2, Cristina Barale2, Giuseppe Poli1, Franco Cavalot2.
Abstract
Postprandial dysmetabolism in type 2 diabetes (T2D) is known to impact the progression and evolution of this complex disease process. However, the underlying pathogenetic mechanisms still require full elucidation to provide guidance for disease prevention and treatment. This review focuses on the marked redox changes and inflammatory stimuli provoked by the spike in blood glucose and lipids in T2D individuals after meals. All the causes of exacerbated postprandial oxidative stress in T2D were analyzed, also considering the consequence of enhanced inflammation on vascular damage. Based on this in-depth analysis, current strategies of prevention and pharmacologic management of T2D were critically reexamined with particular emphasis on their potential redox-related rationale.Entities:
Keywords: oxidative stress; postprandial dysmetabolism; redox signaling; redox-oriented therapy; type 2 diabetes
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Year: 2015 PMID： 25943420 DOI： 10.1002/med.21349
Source DB: PubMed Journal: Med Res Rev ISSN： 0198-6325 Impact factor: 12.944