Literature DB >> 25941616

Lessons from immunology: IL4R directly promotes mammary tumor metastasis.

Katherine T Venmar1, Barbara Fingleton1.   

Abstract

Interleukin-4 (IL4), a Th2 cytokine, signals through IL4 receptors (IL4Rs) to regulate increased lymphocyte proliferation and survival. We have recently discovered that IL4 also promotes these phenotypes in mammary cancer cells expressing IL4Rs to enhance their metastatic ability. Targeting IL4/IL4R signaling on cancer cells themselves may limit metastatic disease.

Entities:  

Keywords:  Akt; Erk; breast cancer; liver metastasis; mTOR; proliferation; survival

Year:  2014        PMID： 25941616      PMCID： PMC4292563          DOI： 10.4161/21624011.2014.955373

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  9 in total

Review 1.  The IL-4 receptor: signaling mechanisms and biologic functions.

Authors:  K Nelms; A D Keegan; J Zamorano; J J Ryan; W E Paul
Journal:  Annu Rev Immunol       Date:  1999       Impact factor: 28.527

2.  IL-4 induces proliferation in prostate cancer PC3 cells under nutrient-depletion stress through the activation of the JNK-pathway and survivin up-regulation.

Authors:  Hernan Roca; Matthew J Craig; Chi Ying; Zachary S Varsos; Paul Czarnieski; Ajjai S Alva; James Hernandez; David Fuller; Stephanie Daignault; Patrick N Healy; Kenneth J Pienta
Journal:  J Cell Biochem       Date:  2012-05       Impact factor: 4.429

Review 3.  Cytokine stimulation of epithelial cancer cells: the similar and divergent functions of IL-4 and IL-13.

Authors:  Miranda A Hallett; Katherine T Venmar; Barbara Fingleton
Journal:  Cancer Res       Date:  2012-12-07       Impact factor: 12.701

4.  Apoptosis resistance in epithelial tumors is mediated by tumor-cell-derived interleukin-4.

Authors:  M Todaro; Y Lombardo; M G Francipane; M Perez Alea; P Cammareri; F Iovino; A B Di Stefano; C Di Bernardo; A Agrusa; G Condorelli; H Walczak; G Stassi
Journal:  Cell Death Differ       Date:  2008-01-18       Impact factor: 15.828

5.  In situ cytokine production by breast cancer tumor-infiltrating lymphocytes.

Authors:  B J Camp; S T Dyhrman; V A Memoli; L A Mott; R J Barth
Journal:  Ann Surg Oncol       Date:  1996-03       Impact factor: 5.344

6.  IL-4-induced Stat6 activities affect apoptosis and gene expression in breast cancer cells.

Authors:  Wen Jie Zhang; Ben Hui Li; Xian Zi Yang; Pin Dong Li; Qin Yuan; Xiao Hong Liu; Shuang Bing Xu; Yan Zhang; Jia Yuan; Glenn S Gerhard; Kathryn K Masker; Cheng Dong; Walter A Koltun; Michael J Chorney
Journal:  Cytokine       Date:  2008-03-14       Impact factor: 3.861

7.  IRS1 is highly expressed in localized breast tumors and regulates the sensitivity of breast cancer cells to chemotherapy, while IRS2 is highly expressed in invasive breast tumors.

Authors:  Holly A Porter; Anthony Perry; Chris Kingsley; Nhan L Tran; Achsah D Keegan
Journal:  Cancer Lett       Date:  2013-04-02       Impact factor: 8.679

8.  IL4 receptor ILR4α regulates metastatic colonization by mammary tumors through multiple signaling pathways.

Authors:  Katherine T Venmar; Kathy J Carter; Daniel G Hwang; E Ashley Dozier; Barbara Fingleton
Journal:  Cancer Res       Date:  2014-06-19       Impact factor: 12.701

9.  Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines.

Authors:  Ilkka S Junttila; Remi J Creusot; Ignacio Moraga; Darren L Bates; Michael T Wong; Michael N Alonso; Megan M Suhoski; Patrick Lupardus; Martin Meier-Schellersheim; Edgar G Engleman; Paul J Utz; C Garrison Fathman; William E Paul; K Christopher Garcia
Journal:  Nat Chem Biol       Date:  2012-10-28       Impact factor: 15.040
  9 in total
  6 in total

1.  Reciprocal fine-tuning of progesterone and prolactin-regulated gene expression in breast cancer cells.

Authors:  Sean M Holloran; Bakhtiyor Nosirov; Katherine R Walter; Gloria M Trinca; Zhao Lai; Victor X Jin; Christy R Hagan
Journal:  Mol Cell Endocrinol       Date:  2020-05-11       Impact factor: 4.102

2.  Neutrophils drive accelerated tumor progression in the collagen-dense mammary tumor microenvironment.

Authors:  María G García-Mendoza; David R Inman; Suzanne M Ponik; Justin J Jeffery; Dagna S Sheerar; Rachel R Van Doorn; Patricia J Keely
Journal:  Breast Cancer Res       Date:  2016-05-11       Impact factor: 6.466

3.  IL-4, a direct target of miR-340/429, is involved in radiation-induced aggressive tumor behavior in human carcinoma cells.

Authors:  Eun Sook Kim; Young Eun Choi; Su Jin Hwang; Young-Hoon Han; Myung-Jin Park; In Hwa Bae
Journal:  Oncotarget       Date:  2016-12-27

4.  miR-500a-5p regulates oxidative stress response genes in breast cancer and predicts cancer survival.

Authors:  Davide Degli Esposti; Vasily N Aushev; Eunjee Lee; Marie-Pierre Cros; Jun Zhu; Zdenko Herceg; Jia Chen; Hector Hernandez-Vargas
Journal:  Sci Rep       Date:  2017-11-21       Impact factor: 4.379

5.  CAR T cell therapy for breast cancer: harnessing the tumor milieu to drive T cell activation.

Authors:  Pradip Bajgain; Supannikar Tawinwung; Lindsey D'Elia; Sujita Sukumaran; Norihiro Watanabe; Valentina Hoyos; Premal Lulla; Malcolm K Brenner; Ann M Leen; Juan F Vera
Journal:  J Immunother Cancer       Date:  2018-05-10       Impact factor: 13.751

6.  Interleukin4Rα (IL4Rα) and IL13Rα1 Are Associated with the Progress of Renal Cell Carcinoma through Janus Kinase 2 (JAK2)/Forkhead Box O3 (FOXO3) Pathways.

Authors:  Mi-Ae Kang; Jongsung Lee; Sang Hoon Ha; Chang Min Lee; Kyoung Min Kim; Kyu Yun Jang; See-Hyoung Park
Journal:  Cancers (Basel)       Date:  2019-09-18       Impact factor: 6.639
  6 in total

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