| Literature DB >> 25941612 |
Inge M Werter1, Famke L Schneiders1, Emmanuel Scotet2, Henk M W Verheul1, Tanja D de Gruijl1, Hans J van der Vliet1.
Abstract
CD1d-restricted invariant natural killer T cells (iNKT) constitute an important immunoregulatory T-cell subset involved in the induction of antitumor immune responses. Here, we provide a view on the recent observation that Vγ9Vδ2-T cells, through trogocytosis of CD1d-containing membrane fragments, have the capacity to act as antigen presenting cells for iNKT.Entities:
Keywords: APC; APC, antigen presenting cells; Ag, antigens; BTN, butyrophilin; BrHPP, bromohydrin pyrophosphate; CD, Cluster of differentiation; CD1d; DN, double negative; GM-CSF, granulocyte-macrophage colony-stimulating factor; IFNγ, interferon γ; IL, interleukine; IPP, isopentenyl pyrophosphate; MHC, major histocompatibility complex; NK, natural killer cells; PBMC, peripheral blood mononuclear cells; TNFα, tumor necrosis factor α; Th1, Type 1 T helper; Th2, Type 2 T helper; Vγ9Vδ2-T cells; i.v., intravenous; iNKT; iNKT, invariant natural killer T cells; moDC, monocyte derived dendritic cells; pAg, phosphoantigens; trogocytosis; α-GalCer, α-galactosylceramide
Year: 2014 PMID： 25941612 PMCID： PMC4292710 DOI： 10.4161/21624011.2014.955343
Source DB: PubMed Journal: Oncoimmunology ISSN： 2162-4011 Impact factor: 8.110