Literature DB >> 25941609

New insights into androgenic immune regulation.

Mohamed Simo Arredouani1.   

Abstract

Androgens negatively affect both central and peripheral immunity. Their potent immunosuppressive ability is thought to lead to gender dimorphism in autoimmune and infectious disease and hamper immunosurveillance of tumors. Therefore, we investigated the molecular underpinnings of androgens suppression of T-cell differentiation and found evidence that developing strategies to counteract these inhibitory effects may foster successful cancer immunotherapy in the future.

Entities:  

Keywords:  PTPN1 phosphatase; androgens; immunosuppression; lymphocyte differentiation

Year:  2014        PMID： 25941609      PMCID： PMC4292726          DOI： 10.4161/21624011.2014.954968

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

1.  Peroxisome proliferator-activated receptor (PPAR)α and -γ regulate IFNγ and IL-17A production by human T cells in a sex-specific way.

Authors:  Monan Angela Zhang; Dorothy Rego; Marina Moshkova; Hania Kebir; Andrzej Chruscinski; Hoangkim Nguyen; Rainer Akkermann; Frank Z Stanczyk; Alexandre Prat; Lawrence Steinman; Shannon E Dunn
Journal:  Proc Natl Acad Sci U S A       Date:  2012-05-30       Impact factor: 11.205

2.  Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination.

Authors:  David Furman; Boris P Hejblum; Noah Simon; Vladimir Jojic; Cornelia L Dekker; Rodolphe Thiébaut; Robert J Tibshirani; Mark M Davis
Journal:  Proc Natl Acad Sci U S A       Date:  2013-12-23       Impact factor: 11.205

3.  Androgens alter T-cell immunity by inhibiting T-helper 1 differentiation.

Authors:  Haydn T Kissick; Martin G Sanda; Laura K Dunn; Kathryn L Pellegrini; Seung T On; Jonathan K Noel; Mohamed S Arredouani
Journal:  Proc Natl Acad Sci U S A       Date:  2014-06-23       Impact factor: 11.205

4.  Androgen ablation augments human HLA2.1-restricted T cell responses to PSA self-antigen in transgenic mice.

Authors:  Mohamed S Arredouani; Stephanie S Tseng-Rogenski; Brent K Hollenbeck; June Escara-Wilke; Karen R Leander; Deborah Defeo-Jones; Clara Hwang; Martin G Sanda
Journal:  Prostate       Date:  2010-06-15       Impact factor: 4.104

5.  Androgens accelerate thymocyte apoptosis.

Authors:  N J Olsen; S M Viselli; J Fan; W J Kovacs
Journal:  Endocrinology       Date:  1998-02       Impact factor: 4.736

6.  Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigen.

Authors:  Charles G Drake; Amy D H Doody; Marianne A Mihalyo; Ching-Tai Huang; Erin Kelleher; Sowmya Ravi; Edward L Hipkiss; Dallas B Flies; Eugene P Kennedy; Meixiao Long; Patrick W McGary; Lee Coryell; William G Nelson; Drew M Pardoll; Adam J Adler
Journal:  Cancer Cell       Date:  2005-03       Impact factor: 31.743

7.  Androgen ablation augments prostate cancer vaccine immunogenicity only when applied after immunization.

Authors:  Yi T Koh; Andrew Gray; Sean A Higgins; Bolyn Hubby; W Martin Kast
Journal:  Prostate       Date:  2009-05-01       Impact factor: 4.104

8.  Immune modulation and increased neurotrophic factor production in multiple sclerosis patients treated with testosterone.

Authors:  Stefan M Gold; Sara Chalifoux; Barbara S Giesser; Rhonda R Voskuhl
Journal:  J Neuroinflammation       Date:  2008-07-31       Impact factor: 8.322

9.  Peroxisome proliferator-activated receptor (PPAR)alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity.

Authors:  Shannon E Dunn; Shalina S Ousman; Raymond A Sobel; Luis Zuniga; Sergio E Baranzini; Sawsan Youssef; Andrea Crowell; John Loh; Jorge Oksenberg; Lawrence Steinman
Journal:  J Exp Med       Date:  2007-01-29       Impact factor: 14.307

Review 10.  The X-files in immunity: sex-based differences predispose immune responses.

Authors:  Eleanor N Fish
Journal:  Nat Rev Immunol       Date:  2008-09       Impact factor: 53.106
  10 in total
  5 in total

1.  Role of Allogeneic Hematopoietic Stem Cell Transplant for Chronic Granulomatous Disease (CGD): a Report of the United States Immunodeficiency Network.

Authors:  Jennifer R Yonkof; Ashish Gupta; Pingfu Fu; Elizabeth Garabedian; Jignesh Dalal
Journal:  J Clin Immunol       Date:  2019-05-20       Impact factor: 8.317

2.  Identification of a Radiosensitivity Molecular Signature Induced by Enzalutamide in Hormone-sensitive and Hormone-resistant Prostate Cancer Cells.

Authors:  Maryam Ghashghaei; Tamim M Niazi; Adriana Aguilar-Mahecha; Kathleen Oros Klein; Celia M T Greenwood; Mark Basik; Thierry M Muanza
Journal:  Sci Rep       Date:  2019-06-20       Impact factor: 4.379

Review 3.  Immune Relevant and Immune Deficient Mice: Options and Opportunities in Translational Research.

Authors:  Enrico Radaelli; Sara F Santagostino; Rani S Sellers; Cory F Brayton
Journal:  ILAR J       Date:  2018-12-31

Review 4.  Emerging Trends in the Epidemiology of COVID-19: The Croatian 'One Health' Perspective.

Authors:  Tatjana Vilibic-Cavlek; Vladimir Stevanovic; Diana Brlek-Gorski; Ivana Ferencak; Thomas Ferenc; Magdalena Ujevic-Bosnjak; Irena Tabain; Natasa Janev-Holcer; Ivana Perkovic; Mario Anticevic; Barbara Bekavac; Bernard Kaic; Anna Mrzljak; Marin Ganjto; Ljiljana Zmak; Maja Mauric Maljkovic; Pavle Jelicic; Lovro Bucic; Ljubo Barbic
Journal:  Viruses       Date:  2021-11-24       Impact factor: 5.048

5.  Gonadectomy effects on the risk of immune disorders in the dog: a retrospective study.

Authors:  Crystal R Sundburg; Janelle M Belanger; Danika L Bannasch; Thomas R Famula; Anita M Oberbauer
Journal:  BMC Vet Res       Date:  2016-12-08       Impact factor: 2.741
  5 in total

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