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Literature DB >> 25941607

Limitations of bystander killing in Th1/M1 immune responses against a secreted tumor antigen.

Anders Aune Tveita¹, Ole Audun Haabeth¹, Bjarne Bogen².

Abstract

T-cell recognition of tumor antigens presented on tumor-infiltrating macrophages (TAMs) induces a tumoricidal M1-like phenotype. Resultant indirect immune responses could eliminate not only antigen secreting (AgPOS), but also antigen negative (AgNEG) tumor cells via bystander killing. Such broad-spectrum response could eliminate antigenically heterogeneous tumors. Using an in vivo model of CD4+ T-cell mediated immunity against MHC II negative myeloma cells, bystander killing of AgNEG cells was ineffective due to strict spatial constraints of Th1-induced TAM cytotoxicity.

Entities: Disease Gene

Keywords: ACT, Adoptive cell therapy; APC, Antigen-presenting cell; Ag, Antigen; CD4+ T cell response; IFN, Interferon gamma; Id, idiotype; LPS, Lipopolysaccharide; NK, Natural killer; SCID, Severe combined immunodeficiency; TAM, Tumor-associated macrophage; TCR-Tg, T-cell receptor transgenic; bystander killing; macrophage cytotoxicity; multiple myeloma

Year: 2014 PMID： 25941607 PMCID： PMC4292458 DOI： 10.4161/21624011.2014.954953

Source DB: PubMed Journal: Oncoimmunology ISSN： 2162-4011 Impact factor: 8.110

10 in total

1. Secretion of tumor-specific antigen by myeloma cells is required for cancer immunosurveillance by CD4+ T cells.

Authors: Alexandre Corthay; Katrin U Lundin; Kristina Berg Lorvik; Peter O Hofgaard; Bjarne Bogen
Journal: Cancer Res Date: 2009-06-30 Impact factor: 12.701

2. Indirect CD4+ T-cell-mediated elimination of MHC II(NEG) tumor cells is spatially restricted and fails to prevent escape of antigen-negative cells.

Authors: Anders A Tveita; Fredrik H Schjesvold; Olav Sundnes; Ole Audun W Haabeth; Guttorm Haraldsen; Bjarne Bogen
Journal: Eur J Immunol Date: 2014-06-20 Impact factor: 5.532

3. Primary antitumor immune response mediated by CD4+ T cells.

Authors: Alexandre Corthay; Dag K Skovseth; Katrin U Lundin; Egil Røsjø; Hilde Omholt; Peter O Hofgaard; Guttorm Haraldsen; Bjarne Bogen
Journal: Immunity Date: 2005-03 Impact factor: 31.745

4. CD4+ T cell--mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFN gamma receptor expression by nonhematopoietic cells.

Authors: Z Qin; T Blankenstein
Journal: Immunity Date: 2000-06 Impact factor: 31.745

5. CD4 cells can be more efficient at tumor rejection than CD8 cells.

Authors: Ainhoa Perez-Diez; Nathalie T Joncker; Kyungho Choi; William F N Chan; Colin C Anderson; Olivier Lantz; Polly Matzinger
Journal: Blood Date: 2007-02-27 Impact factor: 22.113

6. Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma.

Authors: Ying Xie; Akgül Akpinarli; Charles Maris; Edward L Hipkiss; Malcolm Lane; Eun-Kyung M Kwon; Pawel Muranski; Nicholas P Restifo; Paul Andrew Antony
Journal: J Exp Med Date: 2010-02-15 Impact factor: 14.307

7. Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts.

Authors: Sergio A Quezada; Tyler R Simpson; Karl S Peggs; Taha Merghoub; Jelena Vider; Xiaozhou Fan; Ronald Blasberg; Hideo Yagita; Pawel Muranski; Paul A Antony; Nicholas P Restifo; James P Allison
Journal: J Exp Med Date: 2010-02-15 Impact factor: 14.307

8. Naive CD4+ T cells confer idiotype-specific tumor resistance in the absence of antibodies.

Authors: B Bogen; L Munthe; A Sollien; P Hofgaard; H Omholt; F Dagnaes; Z Dembic; G F Lauritzsen
Journal: Eur J Immunol Date: 1995-11 Impact factor: 5.532

9. Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer.

Authors: Ole Audun Werner Haabeth; Kristina Berg Lorvik; Clara Hammarström; Ian M Donaldson; Guttorm Haraldsen; Bjarne Bogen; Alexandre Corthay
Journal: Nat Commun Date: 2011 Impact factor: 14.919

Review 10. How Do CD4(+) T Cells Detect and Eliminate Tumor Cells That Either Lack or Express MHC Class II Molecules?

Authors: Ole Audun Werner Haabeth; Anders Aune Tveita; Marte Fauskanger; Fredrik Schjesvold; Kristina Berg Lorvik; Peter O Hofgaard; Hilde Omholt; Ludvig A Munthe; Zlatko Dembic; Alexandre Corthay; Bjarne Bogen
Journal: Front Immunol Date: 2014-04-15 Impact factor: 7.561