| Literature DB >> 25941585 |
Sakura Hosoba1, Wayne Ac Harris1, Kaifeng L Lin1, Edmund K Waller1.
Abstract
A randomized clinical trial of BM vs. blood stem cell transplants from unrelated donors showed that more plasmacytoid dendritic cells (pDCs) in BM grafts was associated with better post-transplant survival. Here, we describe differences in homing-receptor expression on pDC to explain observed differences following BM vs. blood stem cell transplantation.Keywords: APC, antigen presenting cell; BDCA, blood dendritic cell antigen; BM, bone marrow; BMTCTN, Bone Marrow Transplantation Clinical Trial Network; CCR, C chemokine receptor; CD, cluster of differentiation; CXCR, CX chemokine receptor; G-CSF, granulocyte colony stimulating factor; GVHD, graft vs. host disease; GVL, graft vs. leukemia; HEV, high endothelial venule; HLA-DR, human lymphocyte antigen-DR; IRB, institutional review board; Lin, lineage; PAM, pathogen associated molecular; PB, peripheral blood; PRR, pattern recognition receptor; allo-HSCT, allogeneic hematopoietic stem cell transplantation; antigen presenting; chemokine receptor; graft reject; graft vs. host disease; graft vs. leukemia effect; pDC, plasmacytoid dendritic cell; plasmacytoid dendritic cell; stem cell transplantation
Year: 2014 PMID: 25941585 PMCID: PMC4292210 DOI: 10.4161/21624011.2014.958957
Source DB: PubMed Journal: Oncoimmunology ISSN: 2162-4011 Impact factor: 8.110