E Berardesca1, M Ardigo1, N Cameli2, M Mariano1, M Agozzino1, P J Matts3. 1. San Gallicano Dermatological Institute, Via Chianesi 53, 00144, Rome, Italy. 2. Department of Clinical Dermatology, San Gallicano Institute, Rome, Italy. 3. Procter & Gamble, London Innovation Centre, Egham, Surrey, TW20 9NW, U.K.
Abstract
OBJECTIVE: To investigate the effects of topical application of a Gold Silk Sericin (GSS) complex on biophysical parameters related to skin ageing. METHODS: A range of non-invasive bioengineering methods were deployed in an 8-week randomized, double-blinded, vehicle-controlled, split-face study among 40 female subjects aged 40-70. Endpoints measured included expert grades of skin condition, stratum corneum (SC) hydration, SC barrier function, elasticity and surface topography. RESULTS: The GSS complex produced significant single-variable (P < 0.05) improvements in SC hydration, barrier function, elasticity and surface topography compared with the Vehicle control. CONCLUSION: The GSS complex examined in this study represents an interesting new cosmetic topical technology with which to address multiple aspects of aged/photoaged female facial skin.
RCT Entities:
OBJECTIVE: To investigate the effects of topical application of a Gold Silk Sericin (GSS) complex on biophysical parameters related to skin ageing. METHODS: A range of non-invasive bioengineering methods were deployed in an 8-week randomized, double-blinded, vehicle-controlled, split-face study among 40 female subjects aged 40-70. Endpoints measured included expert grades of skin condition, stratum corneum (SC) hydration, SC barrier function, elasticity and surface topography. RESULTS: The GSS complex produced significant single-variable (P < 0.05) improvements in SC hydration, barrier function, elasticity and surface topography compared with the Vehicle control. CONCLUSION: The GSS complex examined in this study represents an interesting new cosmetic topical technology with which to address multiple aspects of aged/photoaged female facial skin.
Authors: S Nisbet; H Mahalingam; C F Gfeller; E Biggs; S Lucas; M Thompson; M R Cargill; D Moore; S Bielfeldt Journal: Int J Cosmet Sci Date: 2019-02-22 Impact factor: 2.970