Wen-Qiang Wei1, Zhi-Feng Chen1, Yu-Tong He1, Hao Feng1, Jun Hou1, Dong-Mei Lin1, Xin-Qing Li1, Cui-Lan Guo1, Shao-Sen Li1, Guo-Qing Wang1, Zhi-Wei Dong1, Christian C Abnet1, You-Lin Qiao2. 1. Wen-Qiang Wei, Hao Feng, Dong-Mei Lin, Xin-Qing Li, Guo-Qing Wang, Zhi-Wei Dong, and You-Lin Qiao, Cancer Institute/Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing; Zhi-Feng Chen, Yu-Tong He, and Jun Hou, Cancer Institute of Hebei Province, Shijiazhuang; Cui-Lan Guo, Shao-Sen Li, Cancer Institute/Hospital of Ci County, Handan, China; and Christian C. Abnet, National Cancer Institute, Bethesda, MD. 2. Wen-Qiang Wei, Hao Feng, Dong-Mei Lin, Xin-Qing Li, Guo-Qing Wang, Zhi-Wei Dong, and You-Lin Qiao, Cancer Institute/Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing; Zhi-Feng Chen, Yu-Tong He, and Jun Hou, Cancer Institute of Hebei Province, Shijiazhuang; Cui-Lan Guo, Shao-Sen Li, Cancer Institute/Hospital of Ci County, Handan, China; and Christian C. Abnet, National Cancer Institute, Bethesda, MD. qiaoy@cicams.ac.cn.
Abstract
PURPOSE: There are no global screening recommendations for esophageal squamous cell carcinoma (ESCC). Endoscopic screening has been investigated in areas of high incidence in China since the 1970s. This study aimed to evaluate whether an endoscopic screening and intervention program could reduce mortality caused by ESCC. METHODS: Residents age 40 to 69 years were recruited from communities with high rates of ESCC. Fourteen villages were selected as the intervention communities. Ten villages not geographically adjacent to intervention villages were selected for comparison. Participants in the intervention group were screened once by endoscopy with Lugol's iodine staining, and those with dysplasia or occult cancer were treated. All intervention participants and a sample consisting of one tenth of the control group completed questionnaires. We compared cumulative ESCC incidence and mortality between the two groups. RESULTS: Three thousand three hundred nineteen volunteers (48.62%) from an eligible population of 6,827 were screened in the intervention group. Seven hundred ninety-seven volunteers from an eligible population of 6,200 in the control group were interviewed. Six hundred fifty-two incident and 542 fatal ESCCs were identified during the 10-year follow-up. A reduction in cumulative mortality in the intervention group versus the control group was apparent (3.35% v 5.05%, respectively; P < .001). Furthermore, the intervention group had a significantly lower cumulative incidence of ESCC versus the control group (4.17% v 5.92%, respectively; P < .001). CONCLUSION: We showed that endoscopic screening and intervention significantly reduced mortality caused by esophageal cancer. Detection and treatment of preneoplastic lesions also led to a reduction in the incidence of this highly fatal cancer.
PURPOSE: There are no global screening recommendations for esophageal squamous cell carcinoma (ESCC). Endoscopic screening has been investigated in areas of high incidence in China since the 1970s. This study aimed to evaluate whether an endoscopic screening and intervention program could reduce mortality caused by ESCC. METHODS: Residents age 40 to 69 years were recruited from communities with high rates of ESCC. Fourteen villages were selected as the intervention communities. Ten villages not geographically adjacent to intervention villages were selected for comparison. Participants in the intervention group were screened once by endoscopy with Lugol's iodine staining, and those with dysplasia or occult cancer were treated. All intervention participants and a sample consisting of one tenth of the control group completed questionnaires. We compared cumulative ESCC incidence and mortality between the two groups. RESULTS: Three thousand three hundred nineteen volunteers (48.62%) from an eligible population of 6,827 were screened in the intervention group. Seven hundred ninety-seven volunteers from an eligible population of 6,200 in the control group were interviewed. Six hundred fifty-two incident and 542 fatal ESCCs were identified during the 10-year follow-up. A reduction in cumulative mortality in the intervention group versus the control group was apparent (3.35% v 5.05%, respectively; P < .001). Furthermore, the intervention group had a significantly lower cumulative incidence of ESCC versus the control group (4.17% v 5.92%, respectively; P < .001). CONCLUSION: We showed that endoscopic screening and intervention significantly reduced mortality caused by esophageal cancer. Detection and treatment of preneoplastic lesions also led to a reduction in the incidence of this highly fatal cancer.
Authors: G-Q Wang; C C Abnet; Q Shen; K J Lewin; X-D Sun; M J Roth; Y-L Qiao; S D Mark; Z-W Dong; P R Taylor; S M Dawsey Journal: Gut Date: 2005-02 Impact factor: 23.059
Authors: S M Dawsey; G Q Wang; W M Weinstein; K J Lewin; F S Liu; S Wiggett; R K Nieberg; J Y Li; P R Taylor Journal: Gastroenterology Date: 1993-11 Impact factor: 22.682
Authors: Qin-Jing Pan; Mark J Roth; Hui-Qin Guo; Michael L Kochman; Guo-Qing Wang; Michael Henry; Wen-Qiang Wei; Carol A Giffen; Ning Lu; Christian C Abnet; Chang-Qing Hao; Philip R Taylor; You-Lin Qiao; Sanford M Dawsey Journal: Acta Cytol Date: 2008 Jan-Feb Impact factor: 2.319
Authors: Michael M Mwachiro; Stephen L Burgert; Justus Lando; Robert Chepkwony; Collins Bett; Claire Bosire; Christian C Abnet; Jessie Githanga; Wairimu Waweru; Carol A Giffen; Gwen Murphy; Russell E White; Mark D Topazian; Sanford M Dawsey Journal: Am J Gastroenterol Date: 2016-02-23 Impact factor: 10.864
Authors: G Murphy; V McCormack; B Abedi-Ardekani; M Arnold; M C Camargo; N A Dar; S M Dawsey; A Etemadi; R C Fitzgerald; D E Fleischer; N D Freedman; A M Goldstein; S Gopal; M Hashemian; N Hu; P L Hyland; B Kaimila; F Kamangar; R Malekzadeh; C G Mathew; D Menya; G Mulima; M M Mwachiro; A Mwasamwaja; N Pritchett; Y-L Qiao; L F Ribeiro-Pinto; M Ricciardone; J Schüz; F Sitas; P R Taylor; K Van Loon; S-M Wang; W-Q Wei; C P Wild; C Wu; C C Abnet; S J Chanock; P Brennan Journal: Ann Oncol Date: 2017-09-01 Impact factor: 32.976
Authors: Don C Codipilly; Yi Qin; Sanford M Dawsey; John Kisiel; Mark Topazian; David Ahlquist; Prasad G Iyer Journal: Gastrointest Endosc Date: 2018-04-27 Impact factor: 9.427
Authors: Yi Qin; Chung W Wu; William R Taylor; Tarek Sawas; Kelli N Burger; Douglas W Mahoney; Zhifu Sun; Tracy C Yab; Graham P Lidgard; Hatim T Allawi; Navtej S Buttar; Thomas C Smyrk; Prasad G Iyer; David A Katzka; David A Ahlquist; John B Kisiel Journal: Clin Cancer Res Date: 2019-09-16 Impact factor: 12.531