Young-Sun Min1, Hyun-Sul Lim1, Heon Kim2. 1. Department of Preventive Medicine, Dongguk University College of Medicine, Gyeongju-si, South Korea. 2. Department of Preventive Medicine, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju-si, South Korea.
Abstract
BACKGROUND: Limited evidence suggests that human liver toxicity is associated with exposure to polycyclic aromatic hydrocarbons (PAHs). METHODS: The association of urinary PAH metabolites with serum liver enzymes was tested among 288 workers at a petrochemical plant, using a general linear model (GLM) and multiple logistic regression. RESULTS: Urine 2-naphthol levels were positively correlated with serum AST after adjustment for covariates in GLM. Comparing third tertile versus first tertile of 2-naphthol levels, the odds ratios (OR) were elevated for abnormal serum AST levels [OR = 4.1 (95%CI 1.6-10.2)] and abnormal serum ALT levels [OR = 2.4 (95%CI 1.2-4.9)]. CONCLUSIONS: Although confounding by alcohol intake was not completely ruled out, our findings demonstrate an association between PAHs exposure and elevation in serum liver enzymes. Urinary 2-naphthol is a biomarker of exposure to PAHs that is associated with liver toxicity.
BACKGROUND: Limited evidence suggests that humanliver toxicity is associated with exposure to polycyclic aromatic hydrocarbons (PAHs). METHODS: The association of urinary PAH metabolites with serum liver enzymes was tested among 288 workers at a petrochemical plant, using a general linear model (GLM) and multiple logistic regression. RESULTS: Urine 2-naphthol levels were positively correlated with serum AST after adjustment for covariates in GLM. Comparing third tertile versus first tertile of 2-naphthol levels, the odds ratios (OR) were elevated for abnormal serum AST levels [OR = 4.1 (95%CI 1.6-10.2)] and abnormal serum ALT levels [OR = 2.4 (95%CI 1.2-4.9)]. CONCLUSIONS: Although confounding by alcohol intake was not completely ruled out, our findings demonstrate an association between PAHs exposure and elevation in serum liver enzymes. Urinary 2-naphthol is a biomarker of exposure to PAHs that is associated with liver toxicity.
Authors: Si Sun; Weipu Mao; Shuchun Tao; Xiangyu Zou; Shengwei Tian; Siwei Qian; Chi Yao; Guangyuan Zhang; Ming Chen Journal: Int J Gen Med Date: 2021-06-21