Aristeidis Chronopoulos1, Theodora Zarra2, Matthias Tröltzsch3, Salah Mahaini4, Michael Ehrenfeld5, Sven Otto6. 1. Department of Oral and Maxillofacial Surgery, Ludwig-Maximilians-University of Munich, Lindwurmstraße 2a, Munich, 80337, Germany. Electronic address: arisx8@hotmail.com. 2. Department of Endodontology, Dental School, Aristotle University of Thessaloniki, AUTH Campus, Thessaloniki, PC 54124, Greece. Electronic address: theozarra@gmail.com. 3. Department of Oral and Maxillofacial Surgery, Ludwig-Maximilians-University of Munich, Lindwurmstraße 2a, Munich, 80337, Germany. Electronic address: matthias.troeltzsch@med.lmu.de. 4. Department of Oral and Maxillofacial Surgery, Ludwig-Maximilians-University of Munich, Lindwurmstraße 2a, Munich, 80337, Germany. Electronic address: salah.mahaini@med.lmu.de. 5. Department of Oral and Maxillofacial Surgery, Ludwig-Maximilians-University of Munich, Lindwurmstraße 2a, Munich, 80337, Germany. Electronic address: michael.ehrenfeld@med.uni-muenchen.de. 6. Department of Oral and Maxillofacial Surgery, Ludwig-Maximilians-University of Munich, Lindwurmstraße 2a, Munich, 80337, Germany. Electronic address: sven.otto@med.lmu.de.
Abstract
BACKGROUND: Numerous factors have been associated with the development of osteoradionecrosis (ORN) of the jaws. The purpose of this study was to investigate the factors that are linked to the severity of mandibular ORN. METHODS: A retrospective study was conducted which included all ORN cases treated in the Department of Oral and Maxillofacial Surgery in Munich (LMU) between 2003 and 2012. The cases were categorized according to the necrosis stage and several variables were evaluated in order to identify possible correlation between them and the severity of the necrosis. RESULTS: A total of 115 patients with 153 osteonecrosis lesions were included in the study. Twenty-three cases were of stage I, 31 were of stage II and 99 were of stage III. The initial tumors were predominantly located in the floor of the mouth, the tongue or the pharynx. Diabetes mellitus (OR: 4.955, 95% Cl: 1.965-12.495), active smoking (OR: 13.542, 95% Cl: 2.085-87.947), excessive alcohol consumption (OR: 5.428, 95% Cl: 1.622-18.171) and dental treatment and/or local pathological conditions (OR: 0.237, 95% Cl: 0.086-0.655) were significant predictors for stage III necrosis. CONCLUSIONS: The aforementioned factors are predictive of ORN severity and can guide its prophylaxis and management.
BACKGROUND: Numerous factors have been associated with the development of osteoradionecrosis (ORN) of the jaws. The purpose of this study was to investigate the factors that are linked to the severity of mandibular ORN. METHODS: A retrospective study was conducted which included all ORN cases treated in the Department of Oral and Maxillofacial Surgery in Munich (LMU) between 2003 and 2012. The cases were categorized according to the necrosis stage and several variables were evaluated in order to identify possible correlation between them and the severity of the necrosis. RESULTS: A total of 115 patients with 153 osteonecrosis lesions were included in the study. Twenty-three cases were of stage I, 31 were of stage II and 99 were of stage III. The initial tumors were predominantly located in the floor of the mouth, the tongue or the pharynx. Diabetes mellitus (OR: 4.955, 95% Cl: 1.965-12.495), active smoking (OR: 13.542, 95% Cl: 2.085-87.947), excessive alcohol consumption (OR: 5.428, 95% Cl: 1.622-18.171) and dental treatment and/or local pathological conditions (OR: 0.237, 95% Cl: 0.086-0.655) were significant predictors for stage III necrosis. CONCLUSIONS: The aforementioned factors are predictive of ORN severity and can guide its prophylaxis and management.
Authors: Adepitan A Owosho; C Jillian Tsai; Ryan S Lee; Haley Freymiller; Arvin Kadempour; Spyridon Varthis; Adi Z Sax; Evan B Rosen; SaeHee K Yom; Joseph Randazzo; Esther Drill; Elyn Riedel; Snehal Patel; Nancy Y Lee; Joseph M Huryn; Cherry L Estilo Journal: Oral Oncol Date: 2016-12-03 Impact factor: 5.337
Authors: Adepitan A Owosho; Arvin Kadempour; SaeHee K Yom; Joseph Randazzo; C Jillian Tsai; Nancy Y Lee; Ashok R Shaha; Joseph M Huryn; Cherry L Estilo Journal: Oral Oncol Date: 2015-10-09 Impact factor: 5.337