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Literature DB >> 25939065

HIV suppression by host restriction factors and viral immune evasion.

Abstract

Antiviral restriction factors are an integral part of the host innate immune system that protects cells from viral pathogens, such as human immunodeficiency virus (HIV). Studies of the interactions between restriction factors and HIV have greatly advanced our understanding of both the viral life cycle and basic cell biology, as well as provided new opportunities for therapeutic intervention of viral infection. Here we review the recent developments towards establishing the structural and biochemical bases of HIV inhibition by, and viral countermeasures of, the restriction factors TRIM5, MxB, APOBEC3, SAMHD1, and BST2/tetherin.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：
DNA, Viral

Year: 2015 PMID： 25939065 PMCID： PMC4476947 DOI： 10.1016/j.sbi.2015.04.004

Source DB: PubMed Journal: Curr Opin Struct Biol ISSN： 0959-440X Impact factor: 6.809

59 in total

1. Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex.

Authors: Xianghui Yu; Yunkai Yu; Bindong Liu; Kun Luo; Wei Kong; Panyong Mao; Xiao-Fang Yu
Journal: Science Date: 2003-10-16 Impact factor: 47.728

2. Structural insight into HIV-1 capsid recognition by rhesus TRIM5α.

Authors: Haitao Yang; Xiaoyun Ji; Gongpu Zhao; Jiying Ning; Qi Zhao; Christopher Aiken; Angela M Gronenborn; Peijun Zhang; Yong Xiong
Journal: Proc Natl Acad Sci U S A Date: 2012-10-22 Impact factor: 11.205

3. Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain.

Authors: Andreas Hinz; Nolwenn Miguet; Ganesh Natrajan; Yoshiko Usami; Hikaru Yamanaka; Patricia Renesto; Bettina Hartlieb; Andrew A McCarthy; Jean-Pierre Simorre; Heinrich Göttlinger; Winfried Weissenhorn
Journal: Cell Host Microbe Date: 2010-04-22 Impact factor: 21.023

4. The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells.

Authors: Elisa Franzolin; Giovanna Pontarin; Chiara Rampazzo; Cristina Miazzi; Paola Ferraro; Elisa Palumbo; Peter Reichard; Vera Bianchi
Journal: Proc Natl Acad Sci U S A Date: 2013-07-15 Impact factor: 11.205

5. Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu.

Authors: Stuart J D Neil; Trinity Zang; Paul D Bieniasz
Journal: Nature Date: 2008-01-16 Impact factor: 49.962

6. Structural insight into HIV-1 restriction by MxB.

Authors: Jennifer L Fribourgh; Henry C Nguyen; Kenneth A Matreyek; Frances Joan D Alvarez; Brady J Summers; Tamaria G Dewdney; Christopher Aiken; Peijun Zhang; Alan Engelman; Yong Xiong
Journal: Cell Host Microbe Date: 2014-10-09 Impact factor: 21.023

7. The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation.

Authors: Tommy E White; Alberto Brandariz-Nuñez; Jose Carlos Valle-Casuso; Sarah Amie; Laura Anh Nguyen; Baek Kim; Marina Tuzova; Felipe Diaz-Griffero
Journal: Cell Host Microbe Date: 2013-04-17 Impact factor: 21.023

8. The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys.

Authors: Matthew Stremlau; Christopher M Owens; Michel J Perron; Michael Kiessling; Patrick Autissier; Joseph Sodroski
Journal: Nature Date: 2004-02-26 Impact factor: 49.962

9. Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein.

Authors: Kasia Hrecka; Caili Hao; Magda Gierszewska; Selene K Swanson; Malgorzata Kesik-Brodacka; Smita Srivastava; Laurence Florens; Michael P Washburn; Jacek Skowronski
Journal: Nature Date: 2011-06-29 Impact factor: 49.962

10. Transfer of the amino-terminal nuclear envelope targeting domain of human MX2 converts MX1 into an HIV-1 resistance factor.

Authors: Caroline Goujon; Olivier Moncorgé; Hélène Bauby; Tomas Doyle; Wendy S Barclay; Michael H Malim
Journal: J Virol Date: 2014-06-04 Impact factor: 5.103

25 in total

9. The viral protein U (Vpu)-interacting host protein ATP6V0C down-regulates cell-surface expression of tetherin and thereby contributes to HIV-1 release.

Authors: Abdul A Waheed; Maya Swiderski; Ali Khan; Ariana Gitzen; Ahlam Majadly; Eric O Freed
Journal: J Biol Chem Date: 2020-04-14 Impact factor: 5.157

Review 10. HIV-1 and Compromised Adult Neurogenesis: Emerging Evidence for a New Paradigm of HAND Persistence

Authors: Raj Putatunda; Wen-Zhe Ho; Wenhui Hu
Journal: AIDS Rev Date: 2019 Impact factor: 2.500

HIV suppression by host restriction factors and viral immune evasion.

1. Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex.

2. Structural insight into HIV-1 capsid recognition by rhesus TRIM5α.

3. Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain.

4. The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells.

5. Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu.

6. Structural insight into HIV-1 restriction by MxB.

7. The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation.

8. The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys.

9. Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein.

10. Transfer of the amino-terminal nuclear envelope targeting domain of human MX2 converts MX1 into an HIV-1 resistance factor.

1. FEZ1 Is Recruited to a Conserved Cofactor Site on Capsid to Promote HIV-1 Trafficking.

Review 2. HIV-1 capsid: the multifaceted key player in HIV-1 infection.

Review 3. Innate and intrinsic antiviral immunity in Drosophila.

4. Molecular cloning and anti-HIV-1 activities of APOBEC3s from northern pig-tailed macaques (Macaca leonina).

5. A novel HIV-1 inhibitor that blocks viral replication and rescues APOBEC3s by interrupting vif/CBFβ interaction.

Review 6. Cullin-RING E3 Ubiquitin Ligases: Bridges to Destruction.

Review 7. Multiple Inhibitory Factors Act in the Late Phase of HIV-1 Replication: a Systematic Review of the Literature.

8. NF-κB-Interacting Long Noncoding RNA Regulates HIV-1 Replication and Latency by Repressing NF-κB Signaling.

9. The viral protein U (Vpu)-interacting host protein ATP6V0C down-regulates cell-surface expression of tetherin and thereby contributes to HIV-1 release.

Review 10. HIV-1 and Compromised Adult Neurogenesis: Emerging Evidence for a New Paradigm of HAND Persistence