Hani F Ayyash1, Phillip Preece, Richard Morton, Samuele Cortese. 1. Integrated Paediatrics, Child and Adolescent Mental Health Services, Cambridgeshire and Peterborough NHS Mental Health Foundation Trust, A Member of Cambridge University Health Partners, Winchester Place, Peterborough, PE3 6AP, UK.
Abstract
BACKGROUND: Although melatonin is increasingly used for sleep disturbances in children with neurodevelopmental disorders, evidence on effective dose and impact on specific types of sleep disturbance is limited. METHOD: We assessed 45 children (35 males, mean age: 6.3 ± 1.7 years) with neurodevelopmental disorders (n = 29: intellectual disability; n = 9: autism spectrum disorder; n = 7: attention-deficit/hyperactivity disorder) and sleep disturbances, treated with melatonin (mean duration: 326 days) with doses increased according to response. RESULTS: Thirty-eight percent of children responded to low (2.5-3 mg), 31% to medium (5-6 mg) and 9% to high doses (9-10 mg) of melatonin, with a significant increase in total hours of sleep/night, decreased sleep onset delay and decreased number of awakenings/night (all: p = 0.001), as measured with sleep diaries. No serious adverse events were reported. CONCLUSIONS: Melatonin is generally effective and safe in children with neurodevelopmental conditions. Increasing above 6 mg/night adds further benefit only in a small percentage of children.
BACKGROUND: Although melatonin is increasingly used for sleep disturbances in children with neurodevelopmental disorders, evidence on effective dose and impact on specific types of sleep disturbance is limited. METHOD: We assessed 45 children (35 males, mean age: 6.3 ± 1.7 years) with neurodevelopmental disorders (n = 29: intellectual disability; n = 9: autism spectrum disorder; n = 7: attention-deficit/hyperactivity disorder) and sleep disturbances, treated with melatonin (mean duration: 326 days) with doses increased according to response. RESULTS: Thirty-eight percent of children responded to low (2.5-3 mg), 31% to medium (5-6 mg) and 9% to high doses (9-10 mg) of melatonin, with a significant increase in total hours of sleep/night, decreased sleep onset delay and decreased number of awakenings/night (all: p = 0.001), as measured with sleep diaries. No serious adverse events were reported. CONCLUSIONS:Melatonin is generally effective and safe in children with neurodevelopmental conditions. Increasing above 6 mg/night adds further benefit only in a small percentage of children.
Authors: Shweta Anand; Henry Tong; Frank M C Besag; Esther W Chan; Samuele Cortese; Ian C K Wong Journal: Paediatr Drugs Date: 2017-06 Impact factor: 3.022
Authors: Waleed A Al Twaijri; Dua'a Ba Armah; Najla Bin Sabbar; Tariq Aldebasi; Naila Shaheen; Abdul Kareem S Al Bekairy; Majed Al-Jeraisy Journal: J Family Med Prim Care Date: 2022-01-31