Yang Yang1, Jing-Zhu Duan2, Yu Di1, Dong-Mei Gui1, Dian-Wen Gao1. 1. Department of Ophthalmology, China Medical University, Shengjing Hospital, Shenyang 110004, Liaoning Province, China. 2. Department of Orthopedics, China Medical University, Shengjing Hospital, Shenyang 110004, Liaoning Province, China.
Abstract
AIM: To study the gene expression response and predict the network in cell due to pressure effects on optic nerve injury of glaucoma. METHODS: We used glaucoma related microarray data in public database [Gene Expression Omnibus (GEO)] to explore the potential gene expression changes as well as correspondent biological process alterations due to increased pressure in astrocytes during glaucoma development. RESULTS: A total of six genes were identified to be related with pressure increasing. Through the annotation and network analysis, we found these genes might be involved in cell morphological remodeling, angiogenesis, mismatch repair. CONCLUSION: Increasing pressure in glaucoma on astrocytes might cause gene expression alterations, which might induce some cellular responses changes.
AIM: To study the gene expression response and predict the network in cell due to pressure effects on optic nerve injury of glaucoma. METHODS: We used glaucoma related microarray data in public database [Gene Expression Omnibus (GEO)] to explore the potential gene expression changes as well as correspondent biological process alterations due to increased pressure in astrocytes during glaucoma development. RESULTS: A total of six genes were identified to be related with pressure increasing. Through the annotation and network analysis, we found these genes might be involved in cell morphological remodeling, angiogenesis, mismatch repair. CONCLUSION: Increasing pressure in glaucoma on astrocytes might cause gene expression alterations, which might induce some cellular responses changes.
Entities:
Keywords:
astrocytes; glaucoma; high intraocular pressure; microarray
Authors: Alex Yuan; Baseer U Ahmad; David Xu; Rishi P Singh; Peter K Kaiser; Daniel F Martin; Jonathan E Sears; Andrew P Schachat; Justis P Ehlers Journal: Int J Ophthalmol Date: 2014-02-18 Impact factor: 1.779
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