| Literature DB >> 25937524 |
Mizuki Nishino1, Sree H Tirumani2, Nikhil H Ramaiya2, F Stephen Hodi3.
Abstract
The recent advances in the clinical application of anti-cancer immunotherapeutic agents have opened a new arena for the treatment of advanced cancers. Cancer immunotherapy is associated with a variety of important radiographic features in the assessments of tumor response and immune-related adverse events, which calls for radiologists' awareness and in-depth knowledge on the topic. This article will provide the state-of-the art review and perspectives of cancer immunotherapy, including its molecular mechanisms, the strategies for immune-related response assessment on imaging and their pitfalls, and the emerging knowledge of radiologic manifestations of immune-related adverse events. The cutting edge clinical and radiologic investigations are presented to provide future directions.Entities:
Keywords: Cancer; Drug toxicity; Immunotherapy; Oncologic imaging; Tumor response assessment
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Year: 2015 PMID： 25937524 PMCID： PMC4450141 DOI： 10.1016/j.ejrad.2015.03.017
Source DB: PubMed Journal: Eur J Radiol ISSN： 0720-048X Impact factor: 3.528