Jing Xiang1, Milena Korostenskaja2, Cynthia Molloy3, Xinyao deGrauw4, Kimberly Leiken4, Carley Gilman5, Jareen Meinzen-Derr6, Hisako Fujiwara4, Douglas F Rose4, Terry Mitchell7, Donna S Murray8. 1. MEG Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address: Jing.xiang@cchmc.org. 2. MEG Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Functional Brain Mapping and Brain Computer Interface Lab, Comprehensive Pediatric Epilepsy Center, Center for Pediatric Research, Walt Disney Pavilion Florida Hospital for Children, Orlando, FL, USA. 3. Harrison Community Network, Harrison, OH, USA. 4. MEG Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. 5. Center for Autism Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA. 6. Department of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. 7. Harrison Community Network, Harrison, OH, USA; The Kelly O'Leary Center for Autism Spectrum Disorders, Division of Developmental and Behavioral Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. 8. The Kelly O'Leary Center for Autism Spectrum Disorders, Division of Developmental and Behavioral Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Autism Treatment Network, Autism Speaks, 85 Devonshire Street, 9th Floor, Boston, MA, USA.
Abstract
OBJECTIVE: The abnormality of intrinsic brain activity in autism spectrum disorders (ASDs) is still inconclusive. Contradictory results have been found pointing towards hyper-activity or hypo-activity in various brain regions. The present research aims to investigate the spatial and spectral signatures of aberrant brain activity in an unprecedented frequency range of 1-2884 Hz at source levels in ASD using newly developed methods. MATERIALS AND METHODS: Seven ASD subjects and age- and gender-matched controls were studied using a high-sampling rate magnetoencephalography (MEG) system. Brain activity in delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), beta (12-30 Hz), low gamma (30-55 Hz), high gamma (65-90 Hz), ripples (90-200 Hz), high-frequency oscillations (HFOs, 200-1000 Hz), and very high-frequency oscillations (VHFOs, 1000-2884 Hz) was volumetrically localized and measured using wavelet and beamforming. RESULTS: In comparison to controls, ASD subjects had significantly higher odds of alpha activity (8-12 Hz) in the sensorimotor cortex (mu rhythm), and generally high-frequency activity (90-2884 Hz) in the frontal cortex. The source power of HFOs (200-1000 Hz) in the frontal cortex in ASD was significantly elevated as compared with controls. CONCLUSION: The results suggest that ASD has significantly altered intrinsic brain activity in both low- and high-frequency ranges. Increased intrinsic high-frequency activity in the frontal cortex may play a key role in ASD.
OBJECTIVE: The abnormality of intrinsic brain activity in autism spectrum disorders (ASDs) is still inconclusive. Contradictory results have been found pointing towards hyper-activity or hypo-activity in various brain regions. The present research aims to investigate the spatial and spectral signatures of aberrant brain activity in an unprecedented frequency range of 1-2884 Hz at source levels in ASD using newly developed methods. MATERIALS AND METHODS: Seven ASD subjects and age- and gender-matched controls were studied using a high-sampling rate magnetoencephalography (MEG) system. Brain activity in delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), beta (12-30 Hz), low gamma (30-55 Hz), high gamma (65-90 Hz), ripples (90-200 Hz), high-frequency oscillations (HFOs, 200-1000 Hz), and very high-frequency oscillations (VHFOs, 1000-2884 Hz) was volumetrically localized and measured using wavelet and beamforming. RESULTS: In comparison to controls, ASD subjects had significantly higher odds of alpha activity (8-12 Hz) in the sensorimotor cortex (mu rhythm), and generally high-frequency activity (90-2884 Hz) in the frontal cortex. The source power of HFOs (200-1000 Hz) in the frontal cortex in ASD was significantly elevated as compared with controls. CONCLUSION: The results suggest that ASD has significantly altered intrinsic brain activity in both low- and high-frequency ranges. Increased intrinsic high-frequency activity in the frontal cortex may play a key role in ASD.
Authors: Celina A Reis Paula; Camille Reategui; Bruna Karen de Sousa Costa; Caio Queiroz da Fonseca; Luana da Silva; Edgard Morya; Fabricio Lima Brasil Journal: Biomed Res Int Date: 2017-09-06 Impact factor: 3.411