Athina C Tsili1, Anastasios Sylakos2, Alexandra Ntorkou3, Sotirios Stavrou4, Loukas G Astrakas5, Nikolaos Sofikitis6, Maria I Argyropoulou7. 1. Department of Radiology, Medical School, University of Ioannina, 45110 Ioannina, Greece. Electronic address: a_tsili@yahoo.gr. 2. Department of Urology, Medical School, University of Ioannina, 45110 Ioannina, Greece. Electronic address: anasylakos@yahoo.gr. 3. Department of Radiology, Medical School, University of Ioannina, 45110 Ioannina, Greece. Electronic address: alexdorkou@yahoo.com. 4. Department of Urology, Medical School, University of Ioannina, 45110 Ioannina, Greece. Electronic address: s.sotiris@yahoo.gr. 5. Department of Medical Physics, Medical School, University of Ioannina, 45110 Ioannina, Greece. Electronic address: astrakas@uoi.gr. 6. Department of Urology, Medical School, University of Ioannina, 45110 Ioannina, Greece. Electronic address: akrosnin@hotmail.com. 7. Department of Radiology, Medical School, University of Ioannina, 45110 Ioannina, Greece. Electronic address: margyrop@cc.uoi.gr.
Abstract
INTRODUCTION: The aim of this study is to investigate the role of apparent diffusion coefficient (ADC) values and dynamic contrast enhancement (DCE) patterns in differentiating seminomas from nonseminomatous germ cell tumors (NSGCTs). MATERIALS AND METHODS: The MRI examinations of the scrotum of 26 men with histologically proven testicular GCTs were reviewed. DWI was performed in all patients, using a single shot, multi-slice spin-echo planar diffusion pulse sequence and b-values of 0 and 900 s/mm(2). Subtraction DCE-MRI was performed in 20 cases using a 3D fast-field echo sequence after gadolinium administration. Time-signal intensity curves were created and semi-quantitative parameters (peak enhancement, time to peak, wash-in and wash-out rate) were calculated. The Student's t-test was used to compare the mean values of ADC, peak enhancement, time to peak, wash-in and wash-out rate between seminomas and NSGCTs. ROC analysis was also performed. RESULTS: Histopathology disclosed the presence of 15 seminomas and 11 NSGCTs. The mean ± s.d. of ADC values (×10(-3)mm(2)/s) of seminomas (0.59 ± 0.009) were significantly lower than those of NSGCTs (0.90 ± 0.33) (P=0.01). The optimal ADC cut-off value was 0.68 × 10(-3)mm(2)/s. No differences between the two groups were observed for peak enhancement (P=0.18), time to peak (P=0.63) wash-in rate (P=0.32) and wash-out rate (P=0.18). CONCLUSIONS: ADC values may be used to preoperatively differentiate seminomas from NSGCTs.
INTRODUCTION: The aim of this study is to investigate the role of apparent diffusion coefficient (ADC) values and dynamic contrast enhancement (DCE) patterns in differentiating seminomas from nonseminomatous germ cell tumors (NSGCTs). MATERIALS AND METHODS: The MRI examinations of the scrotum of 26 men with histologically proven testicular GCTs were reviewed. DWI was performed in all patients, using a single shot, multi-slice spin-echo planar diffusion pulse sequence and b-values of 0 and 900 s/mm(2). Subtraction DCE-MRI was performed in 20 cases using a 3D fast-field echo sequence after gadolinium administration. Time-signal intensity curves were created and semi-quantitative parameters (peak enhancement, time to peak, wash-in and wash-out rate) were calculated. The Student's t-test was used to compare the mean values of ADC, peak enhancement, time to peak, wash-in and wash-out rate between seminomas and NSGCTs. ROC analysis was also performed. RESULTS: Histopathology disclosed the presence of 15 seminomas and 11 NSGCTs. The mean ± s.d. of ADC values (×10(-3)mm(2)/s) of seminomas (0.59 ± 0.009) were significantly lower than those of NSGCTs (0.90 ± 0.33) (P=0.01). The optimal ADC cut-off value was 0.68 × 10(-3)mm(2)/s. No differences between the two groups were observed for peak enhancement (P=0.18), time to peak (P=0.63) wash-in rate (P=0.32) and wash-out rate (P=0.18). CONCLUSIONS: ADC values may be used to preoperatively differentiate seminomas from NSGCTs.
Authors: Athina C Tsili; Michele Bertolotto; Ahmet Tuncay Turgut; Vikram Dogra; Simon Freeman; Laurence Rocher; Jane Belfield; Michal Studniarek; Alexandra Ntorkou; Lorenzo E Derchi; Raymond Oyen; Parvati Ramchandani; Mustafa Secil; Jonathan Richenberg Journal: Eur Radiol Date: 2017-07-11 Impact factor: 5.315
Authors: Laurence Rocher; Parvati Ramchandani; Jane Belfield; Michele Bertolotto; Lorenzo E Derchi; Jean Michel Correas; Raymond Oyen; Athina C Tsili; Ahmet Tuncay Turgut; Vikram Dogra; Karim Fizazi; Simon Freeman; Jonathan Richenberg Journal: Eur Radiol Date: 2015-10-24 Impact factor: 5.315
Authors: Thomas De Perrot; Christine Sadjo Zoua; Carl G Glessgen; Diomidis Botsikas; Lena Berchtold; Rares Salomir; Sophie De Seigneux; Harriet C Thoeny; Jean-Paul Vallée Journal: J Clin Med Date: 2022-03-30 Impact factor: 4.241