Literature DB >> 25937044

Reprogramming the conduction system: Onward toward a biological pacemaker.

Jason D Meyers1, Patrick Y Jay2, Stacey Rentschler3.   

Abstract

Diseases of the cardiac conduction system can be debilitating and deadly. Electronic pacemakers are incredibly effective in the treatment of sinus and AV node dysfunction, yet there remain important limitations and complications. These issues have driven interest in the development of a biological pacemaker. Here, we review experimental progress in animal models and discuss future directions, with a focus on reprogramming endogenous cells in the heart to treat defects of rhythm and conduction.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 25937044      PMCID： PMC4591112          DOI： 10.1016/j.tcm.2015.03.015

Source DB:  PubMed          Journal:  Trends Cardiovasc Med        ISSN： 1050-1738            Impact factor:   6.677


  46 in total

1.  Minimal "Self" peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles.

Authors:  Pia L Rodriguez; Takamasa Harada; David A Christian; Diego A Pantano; Richard K Tsai; Dennis E Discher
Journal:  Science       Date:  2013-02-22       Impact factor: 47.728

2.  Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors.

Authors:  Young-Jae Nam; Christina Lubczyk; Minoti Bhakta; Tong Zang; Antonio Fernandez-Perez; John McAnally; Rhonda Bassel-Duby; Eric N Olson; Nikhil V Munshi
Journal:  Development       Date:  2014-10-24       Impact factor: 6.868

3.  Implantation of sinoatrial node cells into canine right ventricle: biological pacing appears limited by the substrate.

Authors:  Hao Zhang; David H Lau; Iryna N Shlapakova; Xin Zhao; Peter Danilo; Richard B Robinson; Ira S Cohen; Dan Qu; Zhiyun Xu; Michael R Rosen
Journal:  Cell Transplant       Date:  2011-03-08       Impact factor: 4.064

4.  Canonical wnt signaling regulates atrioventricular junction programming and electrophysiological properties.

Authors:  Benjamin S Gillers; Aditi Chiplunkar; Haytham Aly; Tomas Valenta; Konrad Basler; Vincent M Christoffels; Igor R Efimov; Bastiaan J Boukens; Stacey Rentschler
Journal:  Circ Res       Date:  2014-11-06       Impact factor: 17.367

5.  Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system.

Authors:  Patrick Y Jay; Brett S Harris; Colin T Maguire; Antje Buerger; Hiroko Wakimoto; Makoto Tanaka; Sabina Kupershmidt; Dan M Roden; Thomas M Schultheiss; Terrence X O'Brien; Robert G Gourdie; Charles I Berul; Seigo Izumo
Journal:  J Clin Invest       Date:  2004-04       Impact factor: 14.808

6.  Atrioventricular conduction with and without AV nodal delay: two pathways to the bundle of His in the rabbit heart.

Authors:  William J Hucker; Vinod Sharma; Vladimir P Nikolski; Igor R Efimov
Journal:  Am J Physiol Heart Circ Physiol       Date:  2007-05-11       Impact factor: 4.733

7.  Notch1b and neuregulin are required for specification of central cardiac conduction tissue.

Authors:  David J Milan; Andrea C Giokas; Fabrizio C Serluca; Randall T Peterson; Calum A MacRae
Journal:  Development       Date:  2006-02-15       Impact factor: 6.868

8.  Myocardial Notch signaling reprograms cardiomyocytes to a conduction-like phenotype.

Authors:  Stacey Rentschler; Alberta H Yen; Jia Lu; Nataliya B Petrenko; Min Min Lu; Lauren J Manderfield; Vickas V Patel; Glenn I Fishman; Jonathan A Epstein
Journal:  Circulation       Date:  2012-07-26       Impact factor: 29.690

9.  Early mesodermal cues assign avian cardiac pacemaker fate potential in a tertiary heart field.

Authors:  Michael Bressan; Gary Liu; Takashi Mikawa
Journal:  Science       Date:  2013-03-21       Impact factor: 47.728

10.  Ex vivo, microelectrode analysis of conduction through the AV node of wild-type and Nkx2-5 mutant mouse hearts as guided by a Cx40-eGFP transgenic reporter.

Authors:  Avihu Z Gazit; Alex Li; Jacob S Choi; Lucile Miquerol; Patrick Y Jay
Journal:  Physiol Rep       Date:  2014-04-22
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  6 in total

Review 1.  Modulating Cell Fate as a Therapeutic Strategy.

Authors:  Brian Lin; Priya Srikanth; Alison C Castle; Sagar Nigwekar; Rajeev Malhotra; Jenna L Galloway; David B Sykes; Jayaraj Rajagopal
Journal:  Cell Stem Cell       Date:  2018-06-14       Impact factor: 24.633

Review 2.  New Approaches to Biological Pacemakers: Links to Sinoatrial Node Development.

Authors:  Vasanth Vedantham
Journal:  Trends Mol Med       Date:  2015-11-20       Impact factor: 11.951

3.  Human Organotypic Cultured Cardiac Slices: New Platform For High Throughput Preclinical Human Trials.

Authors:  C Kang; Y Qiao; G Li; K Baechle; P Camelliti; S Rentschler; I R Efimov
Journal:  Sci Rep       Date:  2016-06-30       Impact factor: 4.379

Review 4.  Probing the Electrophysiology of the Developing Heart.

Authors:  Michiko Watanabe; Andrew M Rollins; Luis Polo-Parada; Pei Ma; Shi Gu; Michael W Jenkins
Journal:  J Cardiovasc Dev Dis       Date:  2016-03-22

5.  Genetically engineered mice for combinatorial cardiovascular optobiology.

Authors:  Frank K Lee; Jane C Lee; Bo Shui; Shaun Reining; Megan Jibilian; David M Small; Jason S Jones; Nathaniel H Allan-Rahill; Michael Re Lamont; Megan A Rizzo; Sendoa Tajada; Manuel F Navedo; Luis Fernando Santana; Nozomi Nishimura; Michael I Kotlikoff
Journal:  Elife       Date:  2021-10-29       Impact factor: 8.140

6.  Prenatal ethanol exposure impairs the conduction delay at the atrioventricular junction in the looping heart.

Authors:  Shan Ling; Michael W Jenkins; Michiko Watanabe; Stephanie M Ford; Andrew M Rollins
Journal:  Am J Physiol Heart Circ Physiol       Date:  2021-06-18       Impact factor: 5.125
  6 in total

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