Ibrahim Toprak1, Volkan Yaylalı2, Cem Yildirim2. 1. Department of Ophthalmology, Servergazi State Hospital, Denizli, Turkey. Electronic address: ibrahimt@doctor.com. 2. Department of Ophthalmology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
Abstract
PURPOSE: To evaluate the utility of topographic and pachymetric parameters of Scheimpflug system in keratoconus diagnosis. METHODS: This study included 183 eyes of 183 patients with keratoconus (keratoconus group) and 131 eyes of 131 age and sex-matched healthy subjects (control group). Mean keratometry (K, front), topographic astigmatism, pupil-center pachymetry, apical pachymetry, thinnest pachymetry (TP), corneal volume and maximum K (Kmax) were obtained from the Scheimpflug imaging system. A receiver operating characteristic (ROC) analysis was performed and area under the curve (AUC) was calculated to determine the diagnostic ability of each parameter in eyes with ≤ stage 3, ≤ stage 2 and stage 1 keratoconus based on the Amsler-Krumeich grading system. RESULTS: The Kmax and TP showed the highest individual performance (with sensitivity-specificity of 92.9-92.4% and 89.6-93.3%, respectively) in diagnosis of keratoconus. The AUCs and sensitivity-specificity values for the Kmax/TP and Kmax(2)/TP were calculated to improve the diagnostic performance. As expected, sensitivity-specificity values significantly increased by using Kmax/TP (97.3-94.7% at the level ≥0.08) and Kmax(2)/TP (99.5-95.7% at the level ≥4.1) in discrimination of keratoconic eyes from normals. Moreover, Kmax(2)/TP had very high sensitivity (>99%) and specificity (>94%) in diagnosis of stage 1 and stage 2 keratoconus. CONCLUSIONS: Although Kmax and TP appear to have high diagnostic ability in keratoconus, the use of either single parameter in isolation might be unsatisfactory in differential diagnosis. Therefore, the Kmax(2)/TP ratio has been introduced, which reflects major characteristics of keratoconus and might be used as an important criterion in keratoconus diagnosis.
PURPOSE: To evaluate the utility of topographic and pachymetric parameters of Scheimpflug system in keratoconus diagnosis. METHODS: This study included 183 eyes of 183 patients with keratoconus (keratoconus group) and 131 eyes of 131 age and sex-matched healthy subjects (control group). Mean keratometry (K, front), topographic astigmatism, pupil-center pachymetry, apical pachymetry, thinnest pachymetry (TP), corneal volume and maximum K (Kmax) were obtained from the Scheimpflug imaging system. A receiver operating characteristic (ROC) analysis was performed and area under the curve (AUC) was calculated to determine the diagnostic ability of each parameter in eyes with ≤ stage 3, ≤ stage 2 and stage 1 keratoconus based on the Amsler-Krumeich grading system. RESULTS: The Kmax and TP showed the highest individual performance (with sensitivity-specificity of 92.9-92.4% and 89.6-93.3%, respectively) in diagnosis of keratoconus. The AUCs and sensitivity-specificity values for the Kmax/TP and Kmax(2)/TP were calculated to improve the diagnostic performance. As expected, sensitivity-specificity values significantly increased by using Kmax/TP (97.3-94.7% at the level ≥0.08) and Kmax(2)/TP (99.5-95.7% at the level ≥4.1) in discrimination of keratoconic eyes from normals. Moreover, Kmax(2)/TP had very high sensitivity (>99%) and specificity (>94%) in diagnosis of stage 1 and stage 2 keratoconus. CONCLUSIONS: Although Kmax and TP appear to have high diagnostic ability in keratoconus, the use of either single parameter in isolation might be unsatisfactory in differential diagnosis. Therefore, the Kmax(2)/TP ratio has been introduced, which reflects major characteristics of keratoconus and might be used as an important criterion in keratoconus diagnosis.
Authors: F Cavas-Martínez; E De la Cruz Sánchez; J Nieto Martínez; F J Fernández Cañavate; D G Fernández-Pacheco Journal: Eye Vis (Lond) Date: 2016-02-22
Authors: Mahsaw N Motlagh; Majid Moshirfar; Michael S Murri; David F Skanchy; Hamed Momeni-Moghaddam; Yasmyne C Ronquillo; Phillip C Hoopes Journal: Med Hypothesis Discov Innov Ophthalmol Date: 2019
Authors: Francisco Cavas-Martínez; Laurent Bataille; Daniel G Fernández-Pacheco; Francisco J F Cañavate; Jorge L Alio Journal: Sci Rep Date: 2017-11-20 Impact factor: 4.379