Literature DB >> 25936612

Aspirin-exacerbated respiratory disease: characteristics and management strategies.

Ronald A Simon1, Kristen M Dazy, Jeremy D Waldram.   

Abstract

Aspirin-exacerbated respiratory disease is a clinical entity comprising chronic rhinosinusitis with nasal polyposis, asthma and intolerance to COX-1 inhibiting drugs. The pathogenesis is not completely understood at this point, but abnormal arachidonic acid metabolism is a key feature in this syndrome. The diagnosis is confirmed only by direct drug challenge. Aspirin desensitization followed by daily aspirin therapy is a useful treatment option in these patients. In this review article are discussed the important characteristics and treatment of aspirin-exacerbated respiratory disease.

Entities:  

Keywords:  Samter’s triad; aspirin desensitization; aspirin sensitivity; aspirin-exacerbated respiratory disease; asthma; nasal polyposis; rhinosinusitis

Mesh：

Substances：

Year:  2015        PMID： 25936612     DOI： 10.1586/1744666X.2015.1039940

Source DB:  PubMed          Journal:  Expert Rev Clin Immunol        ISSN： 1744-666X            Impact factor:   4.473


  7 in total

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Authors:  Lin-Shien Fu; Che-Chen Lin; Chia-Yi Wei; Ching-Heng Lin; Yung-Chieh Huang
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  7 in total

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