Jaromír Hanuška1, Cecilia Bonnet2, Jan Rusz3, Tomáš Sieger4, Robert Jech5, Sophie Rivaud-Péchoux6, Marie Vidailhet7, Bertrand Gaymard6, Evžen Růžička8. 1. Dept. of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Dept. of Neurosurgery, Hospital Na Homolce, Prague, Czech Republic. 2. Dept. of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; AP HP, Neurology Department, Pitié Salpêtrière Hospital, Paris, France. 3. Dept. of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Dept. of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University, Prague, Czech Republic. 4. Dept. of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Dept. of Cybernetics, Faculty of Electrical Engineering, Czech Technical University, Prague, Czech Republic. 5. Dept. of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic. 6. CRICM UPMC/INSERM UMR_S975, CNRS UMR7225, ICM, Pitié-Salpêtrière Hospital, Paris, France; Pierre et Marie Curie Paris-6 University, Paris, France. 7. AP HP, Neurology Department, Pitié Salpêtrière Hospital, Paris, France; CRICM UPMC/INSERM UMR_S975, CNRS UMR7225, ICM, Pitié-Salpêtrière Hospital, Paris, France; Pierre et Marie Curie Paris-6 University, Paris, France. 8. Dept. of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic. Electronic address: eruzi@lf1.cuni.cz.
Abstract
BACKGROUND: Blurred near vision is a common non-motor symptom in patients with Parkinson's disease (PD), however detailed characterization of vergence eye movements (VEM) is lacking. METHODS: Convergence and divergence were examined in 18 patients with PD and 18 control subjects using infrared video-oculography. VEM metrics analyzed included latency, velocity and accuracy, in vertical and horizontal planes. RESULTS: The latency of convergence and divergence was significantly increased in PD subjects. Additionally, divergence was slow and hypometric, while other convergence metrics were similar to controls. CONCLUSION: We provide evidence in favor of disrupted VEM in PD.
BACKGROUND: Blurred near vision is a common non-motor symptom in patients with Parkinson's disease (PD), however detailed characterization of vergence eye movements (VEM) is lacking. METHODS: Convergence and divergence were examined in 18 patients with PD and 18 control subjects using infrared video-oculography. VEM metrics analyzed included latency, velocity and accuracy, in vertical and horizontal planes. RESULTS: The latency of convergence and divergence was significantly increased in PD subjects. Additionally, divergence was slow and hypometric, while other convergence metrics were similar to controls. CONCLUSION: We provide evidence in favor of disrupted VEM in PD.
Authors: Carlijn D J M Borm; Katarzyna Smilowska; Nienke M de Vries; Bastiaan R Bloem; Thomas Theelen Journal: J Parkinsons Dis Date: 2019 Impact factor: 5.568