Junna Jwa1, Seung Chik Jwa2, Akira Kuwahara3, Atsumi Yoshida4, Hidekazu Saito5. 1. Division of Reproductive Medicine, Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan; Kiba Park Clinic, Tokyo, Japan. 2. Division of Reproductive Medicine, Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan. Electronic address: jwa-s@ncchd.go.jp. 3. Department of Obstetrics and Gynecology, School of Medicine, University of Tokushima, Tokushima, Japan. 4. Kiba Park Clinic, Tokyo, Japan. 5. Division of Reproductive Medicine, Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.
Abstract
OBJECTIVE: To assess perinatal risk of major congenital anomalies in children born after embryo transfer with assisted hatching (AH). DESIGN: Retrospective cohort study. SETTING: Not applicable. PATIENT(S): Cycles registered from 2010 to 2012 and conceived via single-embryo transfer were included for the analysis. Live births, still births after 22 weeks of gestation, and selectively terminated cases because of congenital anomalies were included. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Major congenital anomaly. RESULT(S): AH was performed in 35,488 cycles among 72,125 included cycles (49.2%). A total of 1,046 major congenital anomalies (1.4%) were identified (1.36% in AH group vs. 1.50% in non-AH group). Overall risks for major congenital anomalies were not significantly different between AH and non-AH groups adjusting for maternal age, calendar year, fetal sex, embryo stage at transfer, and status of cryopreservation. There were 1,009 cases of twins (1.5%) and 10 cases of triplets (0.015%) among all included cycles. No specific organ system demonstrated significant association between AH and non-AH groups. Subgroup analysis demonstrated no significant association between AH and non-AH groups in intracytoplasmic sperm injection cycles or in vitro fertilization in fresh cycles. Similar nonsignificant association was observed between early-cleavage or blastocyst stage at transfer in frozen-thawed cycles. CONCLUSION(S): Our results suggest that AH alone does not increase the risk of major congenital anomaly.
OBJECTIVE: To assess perinatal risk of major congenital anomalies in children born after embryo transfer with assisted hatching (AH). DESIGN: Retrospective cohort study. SETTING: Not applicable. PATIENT(S): Cycles registered from 2010 to 2012 and conceived via single-embryo transfer were included for the analysis. Live births, still births after 22 weeks of gestation, and selectively terminated cases because of congenital anomalies were included. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Major congenital anomaly. RESULT(S): AH was performed in 35,488 cycles among 72,125 included cycles (49.2%). A total of 1,046 major congenital anomalies (1.4%) were identified (1.36% in AH group vs. 1.50% in non-AH group). Overall risks for major congenital anomalies were not significantly different between AH and non-AH groups adjusting for maternal age, calendar year, fetal sex, embryo stage at transfer, and status of cryopreservation. There were 1,009 cases of twins (1.5%) and 10 cases of triplets (0.015%) among all included cycles. No specific organ system demonstrated significant association between AH and non-AH groups. Subgroup analysis demonstrated no significant association between AH and non-AH groups in intracytoplasmic sperm injection cycles or in vitro fertilization in fresh cycles. Similar nonsignificant association was observed between early-cleavage or blastocyst stage at transfer in frozen-thawed cycles. CONCLUSION(S): Our results suggest that AH alone does not increase the risk of major congenital anomaly.
Authors: Sheree L Boulet; Russell S Kirby; Jennita Reefhuis; Yujia Zhang; Saswati Sunderam; Bruce Cohen; Dana Bernson; Glenn Copeland; Marie A Bailey; Denise J Jamieson; Dmitry M Kissin Journal: JAMA Pediatr Date: 2016-06-06 Impact factor: 16.193
Authors: Barbara Luke; Morton B Brown; Ethan Wantman; Nina E Forestieri; Marilyn L Browne; Sarah C Fisher; Mahsa M Yazdy; Mary K Ethen; Mark A Canfield; Stephanie Watkins; Hazel B Nichols; Leslie V Farland; Sergio Oehninger; Kevin J Doody; Michael L Eisenberg; Valerie L Baker Journal: Hum Reprod Date: 2021-01-01 Impact factor: 6.918