Toshiaki Suzuki1, Katsuhito Suwa2, Masaichi Ogawa3, Ken Eto3, Hidejiro Kawahara4, Tetsuji Fujita3, Masahiro Ikegami5, Katsuhiko Yanaga3. 1. Department of Surgery, Daisan Hospital, The Jikei University School of Medicine, Tokyo, Japan. Electronic address: toshiaki1129jp@yahoo.co.jp. 2. Department of Surgery, Daisan Hospital, The Jikei University School of Medicine, Tokyo, Japan. 3. Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan. 4. Department of Surgery, Kashiwa Hospital, The Jikei University School of Medicine, Tokyo, Japan. 5. Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan.
Abstract
BACKGROUND: To evaluate the association of perineural invasion (PNI) with outcomes in patients after colorectal resection of colorectal cancer (CRC) and to assess the effect of PNI on the response to adjuvant chemotherapy. PATIENTS AND METHODS: Data were retrospectively reviewed for 178 patients with consecutive stages I-III CRC who underwent curative surgery between January 1999 and December 2004. PNI data were examined, and the overall survival (OS) and disease-free survival rates were analyzed. RESULTS: PNI was detected in 36 of 178 patients (20%) and positively correlated with lymphatic invasion (P = 0.020), venous invasion (P = 0.037), and the incidence of metastasis or recurrence (P = 0.029). Five-year disease-free survival was 46% and 68% (P < 0.001) and the 5-y OS was 64% and 80% (P < 0.001) for patients with and without PNI, respectively. In stage III CRC, multiple regression analysis identified PNI as a strong negative prognostic factor of OS; among PNI-positive patients, median OS with adjuvant chemotherapy was almost twofold higher than that without adjuvant chemotherapy (6 versus 2.8 y; P = 0.017). CONCLUSIONS: PNI was a poor predictor of survival among patients with stage III CRC, and adjuvant chemotherapy may attenuate the adverse effects of PNI on survival.
BACKGROUND: To evaluate the association of perineural invasion (PNI) with outcomes in patients after colorectal resection of colorectal cancer (CRC) and to assess the effect of PNI on the response to adjuvant chemotherapy. PATIENTS AND METHODS: Data were retrospectively reviewed for 178 patients with consecutive stages I-III CRC who underwent curative surgery between January 1999 and December 2004. PNI data were examined, and the overall survival (OS) and disease-free survival rates were analyzed. RESULTS: PNI was detected in 36 of 178 patients (20%) and positively correlated with lymphatic invasion (P = 0.020), venous invasion (P = 0.037), and the incidence of metastasis or recurrence (P = 0.029). Five-year disease-free survival was 46% and 68% (P < 0.001) and the 5-y OS was 64% and 80% (P < 0.001) for patients with and without PNI, respectively. In stage III CRC, multiple regression analysis identified PNI as a strong negative prognostic factor of OS; among PNI-positive patients, median OS with adjuvant chemotherapy was almost twofold higher than that without adjuvant chemotherapy (6 versus 2.8 y; P = 0.017). CONCLUSIONS: PNI was a poor predictor of survival among patients with stage III CRC, and adjuvant chemotherapy may attenuate the adverse effects of PNI on survival.
Authors: Katelin A Mirkin; Christopher S Hollenbeak; Ali Mohamed; Yuxia Jia; Wafik S El-Deiry; Evangelos Messaris Journal: Cancer Biol Ther Date: 2017-05-05 Impact factor: 4.742
Authors: Yanqi Huang; Lan He; Di Dong; Caiyun Yang; Cuishan Liang; Xin Chen; Zelan Ma; Xiaomei Huang; Su Yao; Changhong Liang; Jie Tian; Zaiyi Liu Journal: Chin J Cancer Res Date: 2018-02 Impact factor: 5.087