Zhenglong Wang 1 , Shaojie Chen , Tingquan Zhou 1 , Li Su 1 , Zhiyu Ling 1 , Jinqi Fan 1 , Weijie Chen 1 , Huaan Du 1 , Jiayi Lu 1 , Yanping Xu 1 , Zhen Tan 1 , Hanxuan Yang 1 , Xinyu Hu 1 , Chengzhi Li 1 , Xue Yan 1 , Guangxin Hu 1 , Chang Liu 1 , Yuehui Yin 2 Show Affiliations »
Abstract
BACKGROUND: The effectiveness of catheter-based renal denervation (RDN) remains controversial. Although the reasons for this have not yet been elucidated, ineffective denervation appears to be an important factor. The present study aimed to investigate the difference in RDN between a saline-irrigated catheter (SIC) and a temperature-controlled catheter (TCC). METHODS: Dogs (n = 6) from the Kunming province in Chinese were ablated; the SIC was introduced into the right renal artery, while the TCC was introduced into the left renal artery. After 6 months, histopathology and renal angiography were performed, and the change in neural density was evaluated using morphometric software. The average values of heart rate (HR), blood pressure (BP), and catecholamine metabolites were assessed at baseline and follow-up. RESULTS: Histopathology showed nerve demyelination and denaturation, as well as interstitial hyperplasia, although these changes were more pronounced when the SIC was used. The change in neural density was greater and ablation was deeper when the SIC was used. Intimal hyperplasia was greater when the TCC was used, whereas medial hyperplasia was greater when the SIC was used. A trend toward a decrease in HR, BP, metanephrine, and normetanephrine between baseline and follow-up was observed. CONCLUSIONS: Our findings suggest that SIC ablation results in more extensive neural degeneration, deeper penetration, and less extensive intimal hyperplasia than TCC ablation for RDN. © American Journal of Hypertension, Ltd 2015. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
BACKGROUND: The effectiveness of catheter-based renal denervation (RDN) remains controversial. Although the reasons for this have not yet been elucidated, ineffective denervation appears to be an important factor. The present study aimed to investigate the difference in RDN between a saline -irrigated catheter (SIC) and a temperature-controlled catheter (TCC). METHODS: Dogs (n = 6) from the Kunming province in Chinese were ablated; the SIC was introduced into the right renal artery, while the TCC was introduced into the left renal artery. After 6 months, histopathology and renal angiography were performed, and the change in neural density was evaluated using morphometric software. The average values of heart rate (HR), blood pressure (BP), and catecholamine metabolites were assessed at baseline and follow-up. RESULTS: Histopathology showed nerve demyelination and denaturation, as well as interstitial hyperplasia , although these changes were more pronounced when the SIC was used. The change in neural density was greater and ablation was deeper when the SIC was used. Intimal hyperplasia was greater when the TCC was used, whereas medial hyperplasia was greater when the SIC was used. A trend toward a decrease in HR, BP, metanephrine , and normetanephrine between baseline and follow-up was observed. CONCLUSIONS: Our findings suggest that SIC ablation results in more extensive neural degeneration , deeper penetration, and less extensive intimal hyperplasia than TCC ablation for RDN. © American Journal of Hypertension, Ltd 2015. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
Entities: Chemical
Disease
Species
Keywords:
blood pressure; degeneration; histopathology; hypertension; intimal hyperplasia; medial hyperplasia; renal denervation; saline-irrigated catheter; temperature-controlled catheter.
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Year: 2015
PMID： 25934968 DOI： 10.1093/ajh/hpv051
Source DB: PubMed Journal: Am J Hypertens ISSN： 0895-7061 Impact factor: 2.689