Literature DB >> 25934595

Cardiomyopathy in a dish: using human inducible pluripotent stem cells to model inherited cardiomyopathies.

Forum Kamdar1, Andre Klaassen Kamdar1, Naoko Koyano-Nakagawa1, Mary G Garry1, Daniel J Garry2.   

Abstract

Inherited cardiomyopathies, including hypertrophic cardiomyopathy, dilated cardiomyopathies, arrythmogenic right ventricular cardiomyopathy, and other inherited forms of heart failure, represent a unique set of genetically defined cardiovascular disease processes. Unraveling the molecular mechanisms of these deadly forms of human heart disease has been challenging, but recent groundbreaking scientific advances in stem cell technology have allowed for the generation of patient-specific human inducible stem cell (hiPSC)-derived cardiomyocytes (CMs). hiPSC-derived CMs retain the genetic blueprint of the patient, they can be maintained in culture, and they recapitulate the phenotypic characteristics of the disease in vitro, thus serving as a disease in a dish. This review provides an overview of in vitro modeling of inherited cardiomyopathies with the use of patient-specific hiPSC-derived CMs.
Copyright © 2015. Published by Elsevier Inc.

Entities:  

Keywords:  Cardiomyopathy; disease models; stem cells

Mesh：

Year:  2015        PMID： 25934595      PMCID： PMC4554831          DOI： 10.1016/j.cardfail.2015.04.010

Source DB:  PubMed          Journal:  J Card Fail        ISSN： 1071-9164            Impact factor:   5.712


  65 in total

1.  Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy.

Authors:  Eduardo Garcia-Gras; Raffaella Lombardi; Michael J Giocondo; James T Willerson; Michael D Schneider; Dirar S Khoury; Ali J Marian
Journal:  J Clin Invest       Date:  2006-07       Impact factor: 14.808

2.  Human Pompe disease-induced pluripotent stem cells for pathogenesis modeling, drug testing and disease marker identification.

Authors:  Hsiang-Po Huang; Pin-Hsun Chen; Wuh-Liang Hwu; Ching-Yu Chuang; Yin-Hsiu Chien; Lee Stone; Chung-Liang Chien; Li-Tzu Li; Shu-Chuan Chiang; Hsin-Fu Chen; Hong-Nerng Ho; Chung-Hsuan Chen; Hung-Chih Kuo
Journal:  Hum Mol Genet       Date:  2011-09-15       Impact factor: 6.150

3.  Generation of human cardiomyocytes: a differentiation protocol from feeder-free human induced pluripotent stem cells.

Authors:  Elisa Di Pasquale; Belle Song; Gianluigi Condorelli
Journal:  J Vis Exp       Date:  2013-06-28       Impact factor: 1.355

4.  Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines.

Authors:  Steven J Kattman; Alec D Witty; Mark Gagliardi; Nicole C Dubois; Maryam Niapour; Akitsu Hotta; James Ellis; Gordon Keller
Journal:  Cell Stem Cell       Date:  2011-02-04       Impact factor: 24.633

5.  Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming.

Authors:  Paul W Burridge; Gordon Keller; Joseph D Gold; Joseph C Wu
Journal:  Cell Stem Cell       Date:  2012-01-06       Impact factor: 24.633

6.  Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy.

Authors:  Ning Sun; Masayuki Yazawa; Jianwei Liu; Leng Han; Veronica Sanchez-Freire; Oscar J Abilez; Enrique G Navarrete; Shijun Hu; Li Wang; Andrew Lee; Aleksandra Pavlovic; Shin Lin; Rui Chen; Roger J Hajjar; Michael P Snyder; Ricardo E Dolmetsch; Manish J Butte; Euan A Ashley; Michael T Longaker; Robert C Robbins; Joseph C Wu
Journal:  Sci Transl Med       Date:  2012-04-18       Impact factor: 17.956

7.  Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia.

Authors:  Christian B Jung; Alessandra Moretti; Michael Mederos y Schnitzler; Laura Iop; Ursula Storch; Milena Bellin; Tatjana Dorn; Sandra Ruppenthal; Sarah Pfeiffer; Alexander Goedel; Ralf J Dirschinger; Melchior Seyfarth; Jason T Lam; Daniel Sinnecker; Thomas Gudermann; Peter Lipp; Karl-Ludwig Laugwitz
Journal:  EMBO Mol Med       Date:  2012-01-25       Impact factor: 12.137

8.  Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes.

Authors:  Elena Matsa; James E Dixon; Christopher Medway; Orestis Georgiou; Minal J Patel; Kevin Morgan; Paul J Kemp; Andrew Staniforth; Ian Mellor; Chris Denning
Journal:  Eur Heart J       Date:  2013-03-06       Impact factor: 29.983

9.  Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome.

Authors:  Milena Bellin; Simona Casini; Richard P Davis; Cristina D'Aniello; Jessica Haas; Dorien Ward-van Oostwaard; Leon G J Tertoolen; Christian B Jung; David A Elliott; Andrea Welling; Karl-Ludwig Laugwitz; Alessandra Moretti; Christine L Mummery
Journal:  EMBO J       Date:  2013-11-08       Impact factor: 11.598

10.  A novel X-linked gene, G4.5. is responsible for Barth syndrome.

Authors:  S Bione; P D'Adamo; E Maestrini; A K Gedeon; P A Bolhuis; D Toniolo
Journal:  Nat Genet       Date:  1996-04       Impact factor: 38.330
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  9 in total

1.  Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy.

Authors:  Gun-Sik Cho; Dong I Lee; Emmanouil Tampakakis; Sean Murphy; Peter Andersen; Hideki Uosaki; Stephen Chelko; Khalid Chakir; Ingie Hong; Kinya Seo; Huei-Sheng Vincent Chen; Xiongwen Chen; Cristina Basso; Steven R Houser; Gordon F Tomaselli; Brian O'Rourke; Daniel P Judge; David A Kass; Chulan Kwon
Journal:  Cell Rep       Date:  2017-01-10       Impact factor: 9.423

Review 2.  Emerging pharmacologic and structural therapies for hypertrophic cardiomyopathy.

Authors:  Daniel J Philipson; Eugene C DePasquale; Eric H Yang; Arnold S Baas
Journal:  Heart Fail Rev       Date:  2017-11       Impact factor: 4.214

3.  Go to the Mattresses: A New Method for Human-Induced Pluripotent Stem Cell-Derived Cardiomyocyte Maturation.

Authors:  Mary G Garry; Daniel J Garry
Journal:  Circ Res       Date:  2015-12-04       Impact factor: 17.367

4.  Viral expression of a SERCA2a-activating PLB mutant improves calcium cycling and synchronicity in dilated cardiomyopathic hiPSC-CMs.

Authors:  Daniel R Stroik; Delaine K Ceholski; Philip A Bidwell; Justyna Mleczko; Paul F Thanel; Forum Kamdar; Joseph M Autry; Razvan L Cornea; David D Thomas
Journal:  J Mol Cell Cardiol       Date:  2019-11-18       Impact factor: 5.000

Review 5.  Genetic, clinical, molecular, and pathogenic aspects of the South Asian-specific polymorphic MYBPC3Δ25bp variant.

Authors:  Mohammed Arif; Pooneh Nabavizadeh; Taejeong Song; Darshini Desai; Rohit Singh; Sholeh Bazrafshan; Mohit Kumar; Yigang Wang; Richard J Gilbert; Perundurai S Dhandapany; Richard C Becker; Evangelia G Kranias; Sakthivel Sadayappan
Journal:  Biophys Rev       Date:  2020-07-12

6.  Stem Cell-Derived Cardiomyocytes and Beta-Adrenergic Receptor Blockade in Duchenne Muscular Dystrophy Cardiomyopathy.

Authors:  Forum Kamdar; Satyabrata Das; Wuming Gong; André Klaassen Kamdar; Tatyana A Meyers; Pruthvi Shah; James M Ervasti; DeWayne Townsend; Timothy J Kamp; Joseph C Wu; Mary G Garry; Jianyi Zhang; Daniel J Garry
Journal:  J Am Coll Cardiol       Date:  2020-03-17       Impact factor: 27.203

Review 7.  Recent Advances in the Molecular Genetics of Familial Hypertrophic Cardiomyopathy in South Asian Descendants.

Authors:  Jessica Kraker; Shiv Kumar Viswanathan; Ralph Knöll; Sakthivel Sadayappan
Journal:  Front Physiol       Date:  2016-10-28       Impact factor: 4.566

8.  Differences in Contractile Function of Myofibrils within Human Embryonic Stem Cell-Derived Cardiomyocytes vs. Adult Ventricular Myofibrils Are Related to Distinct Sarcomeric Protein Isoforms.

Authors:  Bogdan Iorga; Kristin Schwanke; Natalie Weber; Meike Wendland; Stephan Greten; Birgit Piep; Cristobal G Dos Remedios; Ulrich Martin; Robert Zweigerdt; Theresia Kraft; Bernhard Brenner
Journal:  Front Physiol       Date:  2018-01-19       Impact factor: 4.566

9.  Transcriptome Analysis of Cardiac Hypertrophic Growth in MYBPC3-Null Mice Suggests Early Responders in Hypertrophic Remodeling.

Authors:  Emily Farrell; Annie E Armstrong; Adrian C Grimes; Francisco J Naya; Willem J de Lange; J Carter Ralphe
Journal:  Front Physiol       Date:  2018-10-25       Impact factor: 4.566
  9 in total

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