Jizhong Shen1, Yun Fang1, Weihong Ge2. 1. Department of Pharmacy, Drum Tower Hospital Affiliated to Medical School of Nanjing University, 321 Zhongshan Road, Nanjing 210008, Jiangsu, China. 2. Department of Pharmacy, Drum Tower Hospital Affiliated to Medical School of Nanjing University, 321 Zhongshan Road, Nanjing 210008, Jiangsu, China. Electronic address: njglgeweihong@163.com.
Abstract
AIMS: Available evidence supports the emerging hypothesis that the T-Allele of the transcription factor 7-like 2 (TCF7L2) rs7903146 may be associated with the risk of impaired proinsulin conversion, but no consensus was available up to now. METHODS: A computer-based search of electronic databases (PubMed, EMBASE, Cochrane Library) and reference lists of relevant articles was carried out, and then 19 studies involving 15830 subjects were identified. The combined weighted mean difference (WMD) and their corresponding 95% confidence interval (CI) were calculated by a fixed or random effect. RESULTS: In the overall analysis, the T-Allele was observed to be significantly associated with the risk of impaired proinsulin conversion (up-regulate fasting proinsulin concentration WMD -0.40 pM/L (95% CI -0.57 to -0.23); down-regulate fasting insulin concentration 3.86 pM/L (95% CI 1.91 to 5.81)). Subgroup analyse stratified by subjects population characteristics and ethnicity were performed. The results indicated the TCF7L2 rs7903146 polymorphism was associated with the risk of impaired proinsulin conversion in various population characteristics study. With only a few of subjects in Asians and Africans were available, we failed to detect significant ethnic difference about TCF7L2 rs7903146 polymorphism and the risk of impaired proinsulin conversion. CONCLUSIONS: Our results indicated that the T-Allele of the TCF7L2 rs7903146 is a significantly risk factor for impaired proinsulin conversion. Future research should gather more data about the effect of TCF7L2 rs7903146 polymorphism on Asians and Africans.
AIMS: Available evidence supports the emerging hypothesis that the T-Allele of the transcription factor 7-like 2 (TCF7L2) rs7903146 may be associated with the risk of impaired proinsulin conversion, but no consensus was available up to now. METHODS: A computer-based search of electronic databases (PubMed, EMBASE, Cochrane Library) and reference lists of relevant articles was carried out, and then 19 studies involving 15830 subjects were identified. The combined weighted mean difference (WMD) and their corresponding 95% confidence interval (CI) were calculated by a fixed or random effect. RESULTS: In the overall analysis, the T-Allele was observed to be significantly associated with the risk of impaired proinsulin conversion (up-regulate fasting proinsulin concentration WMD -0.40 pM/L (95% CI -0.57 to -0.23); down-regulate fasting insulin concentration 3.86 pM/L (95% CI 1.91 to 5.81)). Subgroup analyse stratified by subjects population characteristics and ethnicity were performed. The results indicated the TCF7L2rs7903146 polymorphism was associated with the risk of impaired proinsulin conversion in various population characteristics study. With only a few of subjects in Asians and Africans were available, we failed to detect significant ethnic difference about TCF7L2rs7903146 polymorphism and the risk of impaired proinsulin conversion. CONCLUSIONS: Our results indicated that the T-Allele of the TCF7L2rs7903146 is a significantly risk factor for impaired proinsulin conversion. Future research should gather more data about the effect of TCF7L2rs7903146 polymorphism on Asians and Africans.
Authors: Jean L Fry; Brooke D Munson; Katherine L Thompson; Christopher S Fry; Douglas Paddon-Jones; Emily J Arentson-Lantz Journal: Sci Rep Date: 2022-04-27 Impact factor: 4.996
Authors: Hassan Ashktorab; Hamed Azimi; Sudhir Varma; Edward L Lee; Adeyinka O Laiyemo; Michael L Nickerson; Hassan Brim Journal: Oncotarget Date: 2019-04-05