Anwar Umar1, Guldiyar Iskandar2, Ainiwaer Aikemu3, Wuliya Yiming2, Wenting Zhou2, Bénedicte Berké4, Bernard Begaud5, Nicholas Moore6. 1. Department of Pharmacology, Xinjiang Medical University, 830011 Urumqi, PR China; Department of Pharmacology - Université Bordeaux Segalen, F-33076 Bordeaux, France. Electronic address: Anwar.umar@126.com. 2. Department of Pharmacology, Xinjiang Medical University, 830011 Urumqi, PR China. 3. Department of Drug Analysis, Xinjiang Medical University, 830011 Urumqi, PR China. 4. Department of Pharmacology - Université Bordeaux Segalen, F-33076 Bordeaux, France. 5. Department of Pharmacology, Xinjiang Medical University, 830011 Urumqi, PR China; Department of Pharmacology - Université Bordeaux Segalen, F-33076 Bordeaux, France. 6. Department of Pharmacology, Xinjiang Medical University, 830011 Urumqi, PR China; Department of Pharmacology - Université Bordeaux Segalen, F-33076 Bordeaux, France; Department of Drug Analysis, Xinjiang Medical University, 830011 Urumqi, PR China. Electronic address: nicholas.moore@pharmaco.u-bordeaux2.fr.
Abstract
OBJECTIVE: To study the effects of Cydonia oblonga Miller (COM) total flavonoids (TF) from leaves and fruit on the blood lipid and antioxidant potentials using hyperlipidaemic rat models. METHODS: Hyperlipidaemic rat models were created with high-lipid emulsion. Rats were distributed into normal controls, hyperlipidaemic models, and daily high (160mg/kg), medium (80mg/kg) and low (40mg/kg) TF from leaves and fruit and simvastatin (5mg/kg) groups. After four weeks, serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), as well as hepatic superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) were measured. RESULTS: Compared with the hyperlipidaemic model group, TF significantly reduced serum TC, TG, LDL-C (P<0.01), ALT and AST (P<0.01 or P<0.05) and increased HDL-C (P<0.05 or P<0.01). TF also reduced MDA (P<0.01 or P<0.01). CONCLUSION: COM total flavonoids can effectively regulate the metabolism of lipids, and remove oxygen free radicals. This confirms its potential value in the prevention and treatment of hyperlipidaemia.
OBJECTIVE: To study the effects of Cydonia oblonga Miller (COM) total flavonoids (TF) from leaves and fruit on the blood lipid and antioxidant potentials using hyperlipidaemic rat models. METHODS: Hyperlipidaemic rat models were created with high-lipid emulsion. Rats were distributed into normal controls, hyperlipidaemic models, and daily high (160mg/kg), medium (80mg/kg) and low (40mg/kg) TF from leaves and fruit and simvastatin (5mg/kg) groups. After four weeks, serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), as well as hepatic superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) were measured. RESULTS: Compared with the hyperlipidaemic model group, TF significantly reduced serum TC, TG, LDL-C (P<0.01), ALT and AST (P<0.01 or P<0.05) and increased HDL-C (P<0.05 or P<0.01). TF also reduced MDA (P<0.01 or P<0.01). CONCLUSION: COM total flavonoids can effectively regulate the metabolism of lipids, and remove oxygen free radicals. This confirms its potential value in the prevention and treatment of hyperlipidaemia.
Authors: Karen Marlenne Herrera-Rocha; Nuria Elizabeth Rocha-Guzmán; José Alberto Gallegos-Infante; Rubén Francisco González-Laredo; Mar Larrosa-Pérez; Martha Rocío Moreno-Jiménez Journal: Molecules Date: 2022-04-11 Impact factor: 4.927