Literature DB >> 25934425

Estimation of Young's modulus of pharmaceutical tablet obtained by terahertz time-delay measurement.

Kai-Erik Peiponen1, Prince Bawuah2, Mousumi Chakraborty2, Mikko Juuti3, J Axel Zeitler4, Jarkko Ketolainen5.   

Abstract

In this paper, it is suggested that Young's modulus of pharmaceutical tablets with different porosity can be estimated from terahertz (THz) pulse time delay. We demonstrate such a possibility using a training set of tablets compressed from starch acetate. Once the mechanical properties are taught to the THz measurement system, using an ideal tablet as a reference, it is possible to get information about the Young's modulus of the tablet. Here, we show that there are optical counterparts of classical mechanical laws that couple the Young's modulus and porosity of the tablet.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Pharmaceutical tablet; Porosity; Refractive index; Spriggs law; Terahertz pulse; Young’s modulus

Mesh:

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Year:  2015        PMID: 25934425     DOI: 10.1016/j.ijpharm.2015.04.068

Source DB:  PubMed          Journal:  Int J Pharm        ISSN: 0378-5173            Impact factor:   5.875


  1 in total

Review 1.  A Review of Disintegration Mechanisms and Measurement Techniques.

Authors:  Daniel Markl; J Axel Zeitler
Journal:  Pharm Res       Date:  2017-03-01       Impact factor: 4.200

  1 in total

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