| Literature DB >> 25934425 |
Kai-Erik Peiponen1, Prince Bawuah2, Mousumi Chakraborty2, Mikko Juuti3, J Axel Zeitler4, Jarkko Ketolainen5.
Abstract
In this paper, it is suggested that Young's modulus of pharmaceutical tablets with different porosity can be estimated from terahertz (THz) pulse time delay. We demonstrate such a possibility using a training set of tablets compressed from starch acetate. Once the mechanical properties are taught to the THz measurement system, using an ideal tablet as a reference, it is possible to get information about the Young's modulus of the tablet. Here, we show that there are optical counterparts of classical mechanical laws that couple the Young's modulus and porosity of the tablet.Entities:
Keywords: Pharmaceutical tablet; Porosity; Refractive index; Spriggs law; Terahertz pulse; Young’s modulus
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Year: 2015 PMID: 25934425 DOI: 10.1016/j.ijpharm.2015.04.068
Source DB: PubMed Journal: Int J Pharm ISSN: 0378-5173 Impact factor: 5.875