| Literature DB >> 25934295 |
Qi Wang1, Ying Sun2, Zhirong Zhang3, Yourong Duan4.
Abstract
Nanoparticles (NPs) have great potential as drug delivery systems or as drugs for treating certain diseases. We designed three NPs with different charges and modifications with PEG to treat tumors. PDLA-CS, PEG-PLGA-PLL, and PEG-PS/CaP NPs were designed and evaluated to assess NPs fate in vivo and efficacy for treating tumors. Comparison between PEG-modified and non-PEG-modified NPs showed that PEG-modified NPs increased K(+) efflux, easily escaped from lysosomes, affected the mitochondria, induced mitochondrial apoptosis, had longer circulation time, and easily targeted tumors. Non-PEG-modified NPs induce the endoplasmic reticulum apoptosis pathway. Comparison between positively and negatively charged NPs showed that negatively charged NPs have less effect on the K(+) efflux of normal cells and more effect on the mitochondrial apoptosis of tumor cells. Positively charged NPs accumulated within the tumors and the liver and lungs. These results provide a theoretical basis for future clinical applications.Entities:
Keywords: Apoptosis pathway; Cell membrane potential; Liver tumors; Polymeric therapeutic nanoparticles
Mesh：
Substances：
Year: 2015 PMID： 25934295 DOI： 10.1016/j.biomaterials.2015.03.050
Source DB: PubMed Journal: Biomaterials ISSN： 0142-9612 Impact factor: 12.479